分光光度法测量生物组织中BPA含量  

Determinate the BPA in Biological Samples by Spectrophotometry

作　　者：李凤林[1] 罗志福[1] 邓新荣[1] 樊彩云[1] 刘子华[1] 吴猛[1] 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413

出　　处：《同位素》2013年第3期163-169,共7页Journal of Isotopes

摘　　要：建立了以3-甲氧基-甲亚胺-H为显色剂的二羟基硼酰苯丙氨酸(P-Boronophenylalanine,BPA)分光光度测量方法,并对该法在样品处理、试剂选择、条件测试等方面进行试验。研究BPA在正常小鼠体内的生物分布,以确定BPA的靶向性和有效性。Boron neutron capture therapy （BNCT） is a new radiation therapy, of which clin- ical interest has focused primarily on the treatment of high-grade gliomas . At present, the most effective drug for BNCT is p-Boronophenylalanine（BPA） , becouse it has little side effect and low toxicity, persisted longer in tumors compared with related molecules. The method of 3-Methoxy-Methylenimine H spectrophotometry was established to measure the concentration of ^10B in biological samples. The biodistribution of the BPA was studied in normal mice.

关 键 词：BNCT BPA 分光光度法 3-甲氧基-甲亚胺-H 生物分布 

分 类 号：O653.7[理学—分析化学] O657.4[理学—化学]