Apelin/APJ系统与器官纤维化关系的研究进展  

Apelin /APJ and Organ Fibrosis

作　　者：王丽妍[1] 丁嘉祥[1] 张东亮[1] 刘文虎[1] 

机构地区：[1]首都医科大学附属北京友谊医院肾内科,北京市100050

出　　处：《中国全科医学》2013年第20期2424-2426,共3页Chinese General Practice

基　　金：北京市自然科学基金课题(7132091);北京市科技计划课题(Z121107001012138);首都卫生发展科研专项课题(首发2011-2002-02)

摘　　要：Apelin是Gi蛋白偶联受体——APJ的内源性配体。Apelin/APJ系统广泛分布在人体的各个组织器官中,参与炎症反应、氧化应激、血管形成、调节激素分泌、维持血管张力和心肌收缩力等多种病理生理过程。Apelin/APJ系统在器官纤维化的发生和发展中也起着重要的作用,由于不同器官的结构和功能不同,其所产生的效应各异。本文就Apelin/APJ系统与几种常见的器官纤维化之间的关系及相关机制做一综述。Apelin is a endogenous ligand of Gi protein coupled receptors———APJ.Apelin/APJ,widely distributed in various tissues and organs in human,is involved in inflammation,oxidative stress,angiogenesis,hormone secretion regulation,vascular tone maintaining,myocardial contractility and other pathophysiological process.Apelin / APJ also plays an important role in the occurrence and development of organ fibrosis.Due to the difference of structures and functions,it generates various effects in different organs.Therefore,this paper reviews the relationships between Apelin / APJ and fibrosis in several common organs,and its potential mechanisms.

关 键 词：APELIN APJ 纤维化 

分 类 号：R692.9[医药卫生—泌尿科学]