慢性阻塞性肺疾病患者血浆纤维蛋白原与冠心病的相关性研究  

The Study of the Correlation of Plasma Fibrinogen Concentration and Coronary Heart Disease with Chronic Obstruc tive Pulmonary Disease

作　　者：竟雪莹[1] 祖磊[1] 桑更生[1] 

机构地区：[1]安徽省蚌埠市第三人民医院心内科,233000

出　　处：《中华全科医学》2013年第10期1540-1541,共2页Chinese Journal of General Practice

摘　　要：目的探讨慢性阻塞性肺疾病（COPD）患者血浆纤维蛋白原浓度与冠心病（CHD）的相关性。方法选择2004—2011年在蚌埠市第三人民医院心内科行冠状动脉造影的患者100例，其中合并慢性阻塞性肺病患者47例归为COPD组，其他53例为对照组，比较两组患者血浆纤维蛋白原浓度、冠脉造影所示冠脉病变严重程度。结果两组患者血浆纤维蛋白原浓度均明显高于正常值；其中COPD组血浆纤维蛋白原浓度较对照组明显升高（P〈0．05），冠脉造影所示冠脉病变Gensini冠状动脉积分两组差异有统计学意义（P〈0．05）。结论COPD患者血浆纤维蛋白原浓度升高，与冠脉病变成明显相关性。Objective To explore correlation of plasma fibrinogen concentration and coronary heart disease（CHD） with chronic obstructive pulmonary disease （COPD）. Methods 100 patients in 2004-2010 who underwent Coronary angiography, which combined patients classified as COPD group in 47 cases with chronic obstructive pulmonary disease, 53 cases of the control group,the plasma fibrinogen levels and the severity of coronary artery lesions were compared in the two groups. Results The plasma fibrinogen levels were significantly higher than normal in two groups of patients ,plasma fibrinogen concentration in COPD group was significantly higher than that of the control group（P 〈 0.05 ）, Gensini coronary integral of Coronary angiography coro- nary lesions had a significant difference in two groups（P 〈 0.05）. Conclusion There was obvious correlation between plasma fibrinogen concentration of COPD patients with coronary artery disease.

关 键 词：慢性阻塞性肺疾病 血浆纤维蛋白原 冠心病 

分 类 号：R563.8[医药卫生—呼吸系统] R541.4[医药卫生—内科学]