结核蛋白芯片检测对结核病诊断的价值  

CLINICAL VALUE OF TUBERCULOSIS PROTEIN CHIP IN DIAGNOSIS OF TUBERCULOSIS

作　　者：吴友根[1] 李朝金[1] 杨兴萍[1] 刘红兵[1] 余碧[1] 肖舒元 张丽[1] 罗菊华[1] 侯松高 

机构地区：[1]四川省攀枝花市十九冶医院,617023

出　　处：《中国煤炭工业医学杂志》2013年第8期1317-1319,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的探讨结核蛋白芯片检测对诊断结核病的价值。方法使用蛋白芯片系统检测血清结核抗体的病例共3 000例,其中结核病357例,非结核病2 643例。我们采用蛋白芯片技术检测结核杆菌中五种成分,即ESAT-6、CFP10、LAM、38kD和16kD,分析其结果。结果 357例结核病患者中共238例结核抗体阳性,2 643例非结核病患者408例阳性,结核蛋白芯片检测的灵敏度为66.7%,特异度为84.6%。结论结核蛋白芯片是诊断结核病的较有效方法,具有特异性好、快速方便等优点,对结核病快速辅助诊断起积极作用。Objective To explore the diagnostic value of tuberculosis protein chip for tuberculosis. Methods The antibody levels of tuberculosis protein ESAT-6,CFP10,16kD, 38kD and LAM in 357 tuberculosis cases and 2643 non- TB cases were detected by protein chip. Results The tuberculosis antibody was positive in 238 of 357 tuberculosis cases and 408 of 2643 non- TB cases. The sensitivity of tuberculosis protein chip was 66.7%, and the specificity was 84. 6%. Conclusion The tuberculosis protein chip is a fast, easy and effective method for the rapid auxiliary diagnosis of the uberculosis.

关 键 词：结核分枝杆菌 蛋白芯片 抗体 结核病诊断 

分 类 号：R52[医药卫生—内科学]