云南省、西藏自治区和新疆维吾尔自治区口岸和边境地区健康儿童肠道病毒监测分析  

Analysis of Enterovirus Surveillance among Healthy Children in Port and Bordering Areas of Yunnan Province,Tibet Autonomous Region and Xinjiang Uygur Autonomous Region in China

作　　者：汪海波[1] 汤晶晶[2] 甫尔哈提·吾守尔[3] 拉巴卓玛[4] 李晓嫘[5] 许文波[5] 温宁[1] 张丽芬[2] 彭立吉[3] 冶秀敏[4] 樊春祥[1] 刘波[6] 张勇[2] 郝利新[1] 罗会明[1] 梁晓峰[7] 

机构地区：[1]中国疾病预防控制中心免疫规划中心,北京100050 [2]云南省疾病预防控制中心,昆明650022 [3]新疆维吾尔自治区疾病预防控制中心,乌鲁木齐830002 [4]西藏自治区疾病预防控制中心,拉萨540100 [5]中国疾病预防控制中心病毒病预防控制所,卫生部医学病毒学和病毒病重点实验室,北京102206 [6]中国疾病预防控制中心实验室管理处,北京102206 [7]中国疾病预防控制中心,北京102206

出　　处：《中国疫苗和免疫》2013年第3期199-203,共5页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解新疆维吾尔自治区、西藏自治区和云南省口岸和边境地区,中国健康儿童和入境外籍儿童肠道病毒(Enterovirus,EV)携带情况。方法在三个省(自治区,下同)口岸和边境地区,邀请<15岁中国籍健康儿童和入境的<15岁外籍儿童参加研究,经研究对象监护人知情同意后,由疾病预防控制中心专业人员调查研究对象的人口学特征、免疫史等信息,并采集粪便标本进行EV的分离和鉴定。结果采集312份外籍儿童粪便标本,非脊髓灰质炎(脊灰)(Non-polio)EV(NPEV)分离率为9.6%,三个省外籍儿童NPEV分离率差异有统计学意义(Χ2=12.71,P<0.01)。三个省共采集中国健康儿童粪便标本425份,分离出2株Ⅰ型脊灰疫苗株病毒和1株Ⅲ型疫苗衍生脊灰病毒,NPEV分离率为13.2%。结论动态监测健康儿童EV,作为急性弛缓性麻痹病例监测系统的有效补充,为维持无脊灰状态提供实验室依据。Objective To find out the carrying status of enterovirus among Chinese healthy children and foreign children entry from ports in Xinjiang Uygur Autonomous Region,Tibet Autonomous Region and,Yunnan province.Methods Along the borderline of selected 3 provinces,Chinese healthy children and foreign children 15 years old were invited to participate in our study.After receiving inform consent of children ＇ s guardian,specialists from centers for disease control and prevention investigated children information about demographic characteristics and immunization history,and collected stool specimens for isolation and intratypic differentiation of enterovirus.Results Totally 312 stool samples of foreign children were collected,non-polio enterovirus （ NPEV ） isolation rate was 9.6 %,and there was statistically significant difference of NPEV isolation rate among 3 provinces （Χ2 =14.73,P〈0.01 ） .425 stool samples of Chinese healthy children were collected in 3 provinces,2 type Ⅰ poliovirus vaccine strains and 1 type Ⅲ vaccine derived poliovirus were isolated,and NPEV isolation rate was 13.2 % .Conclusion Dynamically monitoring enterovirus among healthy children is a valuable supplement of acute flaccid paralysis surveillance system,which can provide laboratory foundation for maintaining polio free.

关 键 词：口岸和边境地区 <15岁中国籍健康儿童 <15岁外籍儿童 肠道病毒 监测 

分 类 号：R373.11[医药卫生—病原生物学]