格氏试剂法合成白藜芦醇  

SYNTHESIS OF RESVERATROL BY GRIGNARD REAGENT

作　　者：许宁侠[1,2] 肖明[2] 马政生[2] 

机构地区：[1]西安外事学院医学院,陕西西安710077 [2]西北大学化工学院,陕西西安710069

出　　处：《精细石油化工》2013年第4期59-62,共4页Speciality Petrochemicals

摘　　要：以对甲氧基苄氯为起始原料,先制得格氏试剂,再与3,5-二甲氧基苯甲醛反应,经脱羟基化和脱甲基化制得反式产物白藜芦醇,产率55%。产物经IR和1 H NMR进行了结构表征。该法具有原料成本低,合成路线步骤少,纯化后产物纯度好,产率较高等优点。p-Methoxybenzyl chloride was used to prepare Grignard reagent and then reacted with 3,5dimethoxy benzaldehyde for obtaining resveratrol after dehydroxylation and demethylation.The productivity of resveratrol is 55%.The structures of the target compound was compared with standard substance and confirmed by IR,1 H NMR.Grignard reagent reaction has been industrialized in tonnage and safe in production.This synthetic method has several advantages such as low cost in raw materials,little synthetic route,high purity and productivity.

关 键 词：白藜芦醇 脱甲基化 格氏试剂 

分 类 号：TQ243.1[化学工程—有机化工]