脐带间充质干细胞移植治疗新生儿缺氧缺血性脑损伤的最新研究进展  

Latest study progress of umbilical cord-derived mesenchymal stem cells treating neonatal hypoxic-ischemic brain damage

作　　者：张德双[1] 王华[1] 白小红[1] 陈娟[1] 

机构地区：[1]四川大学华西第二医院新生儿科,成都610041

出　　处：《中华实用儿科临床杂志》2013年第14期1112-1114,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：重度新生儿HIE可以导致新生儿死亡及儿童脑性瘫痪、智力落后、癫痫等神经系统后遗症，目前尚无根治性措施。干细胞移植疗法为其带来了新的希望。其中，脐带间充质干细胞具有来源丰富、容易提取、倍增时间短、免疫原性低、移植后长时间存活等多种优点，作为治疗新生儿HIE的细胞来源有着广泛的应用前景。Severe neonatal hypoxic-ischemic encephalopathy （HIE）can result in serious outcomes including death during the newborn period and permanent neuropsychological handicaps in the form of cerebral palsy, learning disability, epilepsy and so on. So far, there have been no effective treatments in clinical practice. Stem cell transplanta- tion therapy brings new hope for HIE treatment. Among them, umbilical cord-derived mesenchymal stem cells have many advantages such as rich source, easy collection, shorter doubling time,lower immunogenicity and long-term survi-val af- ter transplantation,it will have a broad application prospects as a cell source for the treatment of neonatal HIE.

关 键 词：脐带 间充质干细胞 治疗 缺氧缺血性脑病 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]