子痫前期患者胎盘UPA及TGF—β1含量变化及意义  

Changes and significance of UPA and TGF-β1 in placenta of patients with preeclampsia

作　　者：周仲元[1] 王晓娟[1] 许雅娟[1] 

机构地区：[1]郑州大学第三附属医院产科,450052

出　　处：《中国实用医刊》2013年第15期12-14,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨子痫前期患者胎盘尿激酶型纤溶酶原激活因子（UPA）和转化生长因子-β1（TGF—β1）含量的变化及其在子痫前期发病中的意义。方法采用酶联免疫吸附法测定57例子痫前期患者（子痫前期组，其中轻度患者24例，重度患者33例）和30例正常晚孕妇女（对照组）胎盘UPA和TGF-β1含量。结果对照组胎盘UPA含量为（32．62±2．85）ng／g，子痫前期组为（11．42±4．67）ng／g，两组比较差异有统计学意义（P〈0．01）；且重度组[（8．11±4．25）ng／g]明显低于轻度组[（15．83±3．07）ng／g]，差异有统计学意义（P〈0．01）。对照组胎盘TGF-β1含量为（0．83±0．21）ng／g，子痫前期组为（1．124±0．37）ng／g，两组比较差异有统计学意义（P〈0．05）；重度子痫前期组为（1．33±0．35）ng／g，显著高于对照组（P〈0．05）；轻、重度组之间比较差异无统计学意义（P〉0．05）。子痫前期患者胎盘UPA和TGF-β1，含量呈负相关（r=-0．652，P〈0．01）。结论子痫前期患者胎盘UPA含量异常下降、TGF-β1含量异常升高与其发病及严重程度有关。Objective To investigate the changes and significance of UPA and TGF-β1 in the e- tiology of preeclampsia（PE）. Methods The levels of UPA and TGF-β1 were determined in 57 patients with PE. The data were compared with those of normal pregnant group （ n = 30 ）. The levels of UPA and TGF-β1 in placenta tissue extraction were measured by means of enzyme linked immunosorbent assay （ELISA）. Results The level of UPA in placenta in PE group [ （ 11.42 ±4. 67 ） ng/g ] was lower than that in normal pregnant group[ （32.62 ±2. 85）ng/g, （P 〈0. 01 ）. The level of UPA in severe PE group [ （ 8.11 ± 4.25 ） ng/g] was lower than that in mild PE group [ （ 15.83 ± 3.07 ） ng/g ] （ P 〈 0.01 ）. The level of TGF-151 in placenta of PE group [ （ 1.12± 0.37 ） ng/g ] was higher than that of normal pregnant group[ （0.83±0.21 ）ng/gl （P 〈 0.05 ）. There was no significant difference in the levels of TGF-β1 be- tween the severe PE group [ （ 1.33 ±0.35 ） ng/g ] and the mild PE group [ （0. 91 ± 0. 41 ） ng/g ] （ P 〉 0.05）. There was a negative correlation between the concentrations of UPA and TGF-β1 in placenta in PE（ r = -0. 652 ,P 〈 0.01 ）. Conclusions The changes of UPA and TGF-β1 are related to the occur- rence and development of PE.

关 键 词：子痫前期 尿激酶型纤溶酶原激活因子 转化生长因子-Β1 胎盘 

分 类 号：R714.245[医药卫生—妇产科学]