单次负荷量阿托伐他汀对不稳定型心绞痛患者介入术后心肌的保护作用  

Effects of large dose of atorvastatin in patients with unstable angina after percutaneous coronary intervention

作　　者：逯保军[1] 刘翔宇[1] 邱在东[1] 王娟[1] 

机构地区：[1]河南省焦作市人民医院心内科,454000

出　　处：《中国实用医刊》2013年第15期63-64,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨经皮冠状动脉介入治疗（PCI）术前服用负荷量（80mg）国产阿托伐他汀对不稳定型心绞痛（UAP）患者PCI术后心肌的保护作用及其安全性。方法选取焦作市人民医院近3年择期行PCI术的UAP患者160例，随机分为他汀强化组和对照组各80例。强化组在常规治疗基础上术前6～12h加用阿托伐他汀80mg，观察两组术后无复流发生情况及肌酸激酶同工酶（CK—MB）和肌钙蛋白T（cTnT）的变化。结果强化组无复流发生率（1．3％）低于对照组（8．8％），两组比较差异有统计学意义（P〈0．05）；强化组术后CK—MB和cTnT水平明显低于对照组，两组比较差异有统计学意义（P〈0．05）。结论患者PCI术前服用80mg阿托伐他汀可降低术后无复流的发生，减少术后心肌损伤，并且安全性较好。Objective To investigate the effects and safety of taking large dose （80 mg）of atorvasta- tin before percutaneous coronary intervention（PCI）on postoperative myocardial damage in patients with unsta- ble angina. Methods One hundred and sixty patients who underwent PCI in the past three years in Jiaozuo people＇s hospital were selected, they were randomly divided into intensive group and control group, 80 pa- tients in each group. Patients in both groups were treated with conventional therapy of PCI ,and the patients in intensive group were given large dose of atorvastatin（80 rag,6 -12 hours before operation）. The changs of no- reflow occurrence ,isoenzymes of creatine kinase MB（CK-MB） and troponin T（cTNT） were observed. Results The incidence of no-reflow occurrence in intensive group was significantly lower than that in control group （1.3% vs 8. 8%, P 〈 0. 05）. The level of CK-MB and cTNT in intensive group after operation were lower than that of control group （P 〈 0. 05）. Conclusions Taking large dose of atorvastatin is safe and may re-duce incidence of no re-flow and postoperative myocardial damage.

关 键 词：阿托伐他汀 不稳定型心绞痛 经皮冠状动脉介入治疗术 无复流 

分 类 号：R541.4[医药卫生—心血管疾病]