逍遥散对慢性应激下HPA轴的调节及作用机制的研究进展  

The Study of Mechanism and Regulation of Xiaoyao Powder to HPA Axis under Chronic Stress

作　　者：保芸[1,2] 张汝学[1] 贾正平[1] 

机构地区：[1]全军高原环境损伤防治重点实验室/兰州军区兰州总医院国家中医药管理局临床中药学重点学科,兰州730050 [2]兰州大学,兰州730000

出　　处：《医学综述》2013年第15期2702-2704,共3页Medical Recapitulate

基　　金：国家自然科学基金(81173620)

摘　　要：下丘脑-垂体-肾上腺轴(HPA轴)为应激反应的核心反应轴路,慢性应激可引发机体广泛的适应性调节变化并伴有许多病理效应,许多疾病的诱发均与慢性应激有关。大量试验研究证明逍遥散对于慢性应激引起的HPA轴亢进的有关疾病有明显的调节改善作用。该文针对慢性应激下诱发的HPA轴亢进,综述逍遥散在各个环节对大鼠HPA轴相关因素的调节作用及调节机制,旨在为逍遥散可能的临床治疗领域提供依据。Hypothalamic-pituitary-adrenocortical（HPA） axis,which belongs to neural and immune system,is core of chronic stress causing organism variation and pathological effect,and a lot of diseases are related to chronic stress.A great many of experiments have proved that Xiaoyao powder could regulate HPA axis hyperfunction caused by chronic stress.Here is to make a review of the function and mechanisms of Xiaoyao powder for HPA axis hyperfunction caused by chronic stress in rats,to provide references for the possible clinical fields of Xiaoyao powder.

关 键 词：逍遥散 下丘脑-垂体-肾上腺轴 慢性应激 

分 类 号：R285[医药卫生—中药学]