miRNA在胰岛素抵抗和心力衰竭中的病理生理学作用研究进展  

Research Progress in Pathophysiological Effects of miRNAs on Insulin Resistance and Heart Failure

作　　者：吴红明[1] 钱金桥[1] 

机构地区：[1]昆明医科大学第一附属医院麻醉科,昆明650032

出　　处：《医学综述》2013年第15期2705-2707,共3页Medical Recapitulate

基　　金：国家自然科学基金(81160035)

摘　　要：microRNA又称miRNA,是存在于真核生物细胞中的一类内源性的非编码小分子RNA。生物体中,miRNA能够在转录后水平调控基因的表达,广泛参与生物发育、细胞分化、细胞凋亡等多种生命进程和病理生理过程。胰岛素抵抗在多种疾病和病理生理过程中普遍存在,并诱发和(或)加重糖尿病及心力衰竭。目前认为,miRNA在胰岛素抵抗和心力衰竭的发生、发展中起重要作用。MicroRNAs,also called miRNAs,are endogenous noncoding small RNAs in eukaryotic cells.In many organisms,miRNAs can regulate gene expression at post-transcriptional level,and extensively participate in biological development,cell differentiation,apoptosis,and many other physiological and pathological processes.Insulin resistance which is prevalent in many diseases and physiological and pathological processes inducing and / or aggravating diabetes,cardiomyopathy and heart failure.Studies have confirmed that miRNAs play a certain role in the occurrence of insulin resistance and heart failure.

关 键 词：MIRNA 胰岛素抵抗 心力衰竭 

分 类 号：R541.61[医药卫生—心血管疾病]