他汀在冠状动脉介入治疗中对内皮祖细胞的作用  

The Effect of Statins on Endothlial Progenitor Cells in Percutaneous Coronary Intervention

作　　者：贺甫威[1] 叶红华[2] 

机构地区：[1]宁波大学医学院,浙江宁波315211 [2]宁波市第一医院心脏中心,浙江宁波315010

出　　处：《医学综述》2013年第15期2716-2718,共3页Medical Recapitulate

摘　　要：经皮冠状动脉介入治疗(PCI)技术于近10年突飞猛进,技术逐渐走向成熟。但PCI治疗在给人们带来获益的同时也会对局部血管内皮造成损伤并可能影响患者近远期预后。新近研究表明围术期他汀强化治疗可以减少PCI带来的损伤并改善患者预后。围术期他汀强化治疗带来的获益来自于他汀药物的生物学多效性,可能的机制包括改善血管内皮功能、抗炎、抗氧化、稳定斑块、抑制血小板聚集及对骨髓内皮祖细胞的动员;其中他汀对骨髓内皮祖细胞的动员作用可能为其重要机制。Percutaneous coronary intervention（PCI） has grown by leaps and bounds in the recent 10 years.PCI is associated with mechanical endovascular injury and endothelial denudation which may affect prognosis of patients when it brings benefitIntensive treatment with statin in perioperation of PCI has been proved effective.This benefit comes from multiple biological effects of statin including improving endothelial function,anti-inflammatory,antioxidant,stabling plaque,restraining platelet aggregation and mobilizing endothelial progenitors cells.The role of statin to mobilize endothelial progenitors cells may be a most important mechanism.

关 键 词：内皮祖细胞 冠状动脉粥样硬化性心脏病冠状动脉介入治疗 他汀类药物 

分 类 号：R543.31[医药卫生—心血管疾病]