甲状旁腺癌的分子生物遗传学研究进展  

Research Progress in Molecular Biological Genetics of Parathyroid Carcinoma

作　　者：韩华中[1] 杨俊[2] 

机构地区：[1]苏州大学医学部,江苏苏州215325 [2]上海交通大学附属上海第六人民医院普外科,上海200233

出　　处：《医学综述》2013年第15期2751-2754,共4页Medical Recapitulate

摘　　要：甲状旁腺癌是一种少见的内分泌系统恶性肿瘤,在原发性甲状旁腺功能亢进患者中的发病率为0.1%~5.0%,主要临床表现为高钙血症、高甲状旁腺素血症及颈部肿块等。由于该病的病因不明,且早期常缺乏典型的临床表现,诊断较为困难,往往造成误诊,延误治疗,造成严重后果。因此,早期诊断和早期治疗对甲状旁腺肿瘤有着重要意义。许多研究者寄希望于相关的分子生物遗传学研究取得突破。近年来,有关甲状旁腺癌的分子生物遗传学的研究取得了一些成果,该文就相关研究进展予以综述。Parathyroid carcinoma is a rare endocrine system malignant tumor,and its incidence is 0.1% 5.0% among primary hyperthyroidism patients,main clinical features of which are hypercalcemia,high parathormone acidosis and neck mass,etc..It is often lack of typical clinical manifestations in early stages.The main principle is detecting and treating in time.It is of great significance that early diagnosis and early treatmentbe dlivered.Because the etiology of disease is unknown and the diagnosis is difficult,many researchers hope that molecular biology genetics researches make breakthroughs.In recent years,the research of parathyroid carcinoma molecular biology genetics is making some progress,and here is to make a review of the progress.

关 键 词：甲状旁腺癌 甲状旁腺功能亢进 分子生物遗传学 

分 类 号：R582[医药卫生—内分泌]