质子泵抑制剂治疗慢性阻塞性肺疾病急性加重期合并胃食管反流疾病对肺功能的影响  

Proton pump inhibitors effects on pulmonary function for acute exacerbation of chronic obstructive pulmonary disease combined gastroesophageal reflux.

作　　者：昝海峰[1] 高凌云[1] 陶绍华[1] 

机构地区：[1]成都大学附属医院呼吸科,四川成都610081

出　　处：《四川医学》2013年第5期603-604,共2页Sichuan Medical Journal

摘　　要：目的研究质子泵抑制剂（PPI）治疗慢性阻塞性肺疾病急性加重期（AECOPD）合并胃食管反流疾病（GERD）对肺功能的影响。方法对98例AECOPD合并GERD的患者随机分为两组，实验组48例，对照组50例，对照组给予抗感染、解痉、平喘、祛痰等常规治疗；实验组在此基础上加用奥美拉唑治疗。两组治疗前、后均行肺通气功能检测。结果实验组的各项肺通气功能指标均高于对照组（P〈0．05）。结论AECOPD合并GER的患者治疗方案中加PPI治疗后，可改善患者的肺通气功能。Objective To evaluate the proton pump inhibitors（PPI） effects on pulmonary function for acute exacerbation of chronic obstructive pulmonary disease （AECOPD） combined gastroesophageal reflux disease （GERD）. Methods 98 patients with AECOPD combined GERD were randomly divided into two groups ：the experimental group （48 cases） and the control group （50 eases）. The control group was given conventional treatment of anti-infective, antispasmodic, antiasthmatic, expectorant; experimental group plus omeprazole treatment on this basis. Pulmonary ventilation function were tested before and after treatment. Results The pulmonary ventilation function in experimental group were significantly higher （P 〈 0.05） than that in control group after treatment. Conclusion PPI therapy can improve ventilatory function for AECOPD combined GERD.

关 键 词：质子泵抑制剂 慢性阻塞性肺疾病 胃食管反流疾病 肺功能 

分 类 号：R562[医药卫生—呼吸系统]