袋式输液器对5种药物的吸附性观察  

The absorption study of the Bag-Type infusion on 5 drugs

作　　者：朱九群[1] 兰婉玲 何林[1] 

机构地区：[1]四川省医学科学院.四川省人民医院药剂科,四川成都610072 [2]四川省食品药品检验所,四川成都610097

出　　处：《四川医学》2013年第6期907-908,共2页Sichuan Medical Journal

摘　　要：目的观察袋式输液器对5种药物吸附性。方法按照临床的用药习惯,分别将5种药物加入袋式输液器中,用HPLC法测定其0、1、2、4、8h的的百分含量,以0h的百分含量为参照计算吸附率。结果袋式输液器对甲硝唑、林可霉素、氧氟沙星、人参皂苷Re基本没有吸附;对人参皂苷Rg1、大豆油及卵磷脂有吸附,特别是对卵磷脂吸附较强,8h的吸附率约为10%。结论袋式输液器对部分药物有较强吸附临床应避免这些药物在袋式输液器中使用。Objective To study the absorption of the bag-type infusion on 7 drugs.Methods 5 injections including 7 drugs were put into the bag-type infusion according to clinical method.The contents of the drugs in the bags were determined at different time by HPLC.The absorption ratios of the bags were calculated comparing to the zero tome.Results There were almost no absorptions to metronidazole,lincomycin,ofloxacin,ginsenoside Re,but there were some absorption to ginsenoside Rg1、soybean oil and phosphatidylcholine,especially to phosphatidylcholine for 8% absorption ratio at 8 hours.Conclusion There are strong absorptions for some drugs which should be avoided in clinical use with bag-type infusion.

关 键 词：袋式输液器 高效液相色谱法 药物吸附 

分 类 号：R472[医药卫生—护理学]