Th17细胞和Treg细胞与急性冠状动脉综合征相关性研究进展  

Research Progress on Relationship Between Th17/Treg Cells and Acute Coronary Syndrome

作　　者：朱治蓉 潘薇[1] 

机构地区：[1]哈尔滨医科大学附属第一医院CCU病房,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2013年第4期583-585,共3页Advances in Cardiovascular Diseases

摘　　要：辅助性T细胞17(T helper 17 cells,Th17)和调节性T细胞(T regulatory cells,Treg)是近年来发现的两种新的CD4+T细胞亚群。Th17能够分泌细胞因子参与炎症反应,急性冠状动脉综合征患者Th17激活,其上调水平与斑块的不稳定密切相关。Treg能够分泌细胞因子抑制炎症反应,维持自身免疫平衡,对动脉硬化具有保护作用。有研究表明急性冠状动脉综合征的发病机制中Th17/Treg的失衡导致炎症和斑块不稳定可能是重要的原因。T helper 17 cells（Th17） and T regulatory cells（Treg） are two novel cells found in CD4 ＋ T cell subsets.Th17 cells are activated in acute coronary syndrome（ACS） patients.The active Th17 cells then secrete cytokines that are involved in the inflammation response.The up-regulation of Th17 cells is closely related to plaque instability.However,cytokines secreted by Treg cells are protective against atherosclerosis by inhibiting the inflammation response and maintaining the balance of self-immunity.Studies have shown that inflammatory and plaque instability caused by the imbalance of Th17 / Treg may be the main reason for the pathogenesis of ACS.

关 键 词：TH17 TREG 急性冠状动脉综合征 炎症因子 

分 类 号：R541.4[医药卫生—心血管疾病]