多潘立酮预防阿奇霉素胃肠道反应的疗效观察  

Efficacy of Domperidone in Prevention of Azithromycin-Induced Gastrointestinal Adverse Effects

作　　者：邓益斌[1] 潘攀[1] 肖玉荣[1] 梁予红[1] 罗小华[1] 

机构地区：[1]四川省科学城医院,四川绵阳621900

出　　处：《儿科药学杂志》2013年第8期27-28,共2页Journal of Pediatric Pharmacy

摘　　要：目的:观察多潘立酮混悬液预防静脉滴注阿奇霉素时胃肠道反应的临床效果。方法:128例呼吸道感染并在我院静脉滴注阿奇霉素治疗的患儿,随机分为治疗组和对照组各64例。治疗组于静脉滴注阿奇霉素30 min前给予多潘立酮混悬液0.3 mL/kg口服,对照组不给予任何干预,观察两组在阿奇霉素静脉滴注时胃肠道反应(包括腹痛、腹泻、恶心、呕吐)的发生情况。结果:治疗组阿奇霉素静脉滴注后胃肠道反应发生率低于对照组,两组比较差异有统计学意义(χ2=7.38,P<0.05)。结论:口服多潘立酮混悬液可明显减轻阿奇霉素静脉滴注时出现的胃肠道反应,并且能避免严重不良反应的发生。Objective： To observe the clinical effect of domperidone suspension in prevention of intravenous azithromycin-induced gastrointestinal side effects. Methods： One hundred and twenty-eight cases with respiratory infections were randomly divided into a treatment group and a control group equally. The treatment group received domperidone suspension 0. 3 mL/kg orally 30 min before intravenous drip of azithromycin; the control group was not given any intervention. The gastrointestinal side effects caused by azithromycin （including abdominal pain, diarrhea, nausea, vomiting） were observed. Results： The gastrointestinal side effects in the treatment group were significantly lower than those in the control group. The difference were statistically significant （X2= 7.38, P〈0.05 ）. Conclusions： Oral domperidone suspension can significantly reduce the gastrointestinal side-effects of azithromycin, and avoid the occurrence of severe side effects.

关 键 词：多潘立酮混悬液 阿奇霉素 不良反应 预防 

分 类 号：R720.5[医药卫生—儿科]