蛋白质的连接模型及机理研究  

Research of protein binding model and binding mechanisms

作　　者：杨力权[1,2] 桑鹏[2] 李珍贵[1] 

机构地区：[1]大理学院农学与生物科学学院,云南大理671003 [2]云南大学云南省生物资源保护与利用重点实验室,云南昆明650091

出　　处：《楚雄师范学院学报》2013年第6期61-64,101,共5页Journal of Chuxiong Normal University

基　　金：云南省教育厅基金项目(2012Y150)

摘　　要：蛋白质是通过与其他蛋白质或生物分子的识别和连接来发挥功能的,阐明连接的驱动力及机理对理解蛋白质的功能发挥有很大帮助。文章对三种蛋白质连接的模型进行了描述和比较,对三种模型的驱动力和机理进行了研究,强调了蛋白质的连接是由热力学的熵焓互补平衡控制的过程。Proteins realize their function through recognizing and binding with other proteins or bio - molecules. Unraveling the driving forces and mechanisms underlying binding process are very useful in understanding protein function. In this article, three protein binding models are discussed and com- pared. Subsequently, the driving forces and mechanisms underlying three binding process, are studied and discussed. Finally, we highlight that protein binding is driven by the decrease in total Gibbs free energy through the entropy -enthalpy compensation.

关 键 词：蛋白质连接 连接机理 构象选择模型 吉布斯自由能 熵焓互补 

分 类 号：Q51[生物学—生物化学]