妊娠期妇女伴发早期心功能及心肌细胞损害的监测  

Early injury monitoring of cardiac function and myocardial cells in pregnant women

作　　者：高长杰[1] 杨文东[2] 

机构地区：[1]胜利油田中心医院,山东东营257034 [2]山东省利津县第二人民医院,山东东营257447

出　　处：《实验与检验医学》2013年第4期341-343,共3页Experimental and Laboratory Medicine

摘　　要：目的通过观察妊娠期妇女血清N末端B型钠尿肽原(NT-proBNP)和心脏型脂肪酸结合蛋白(h-FABP)水平变化,探讨其伴发早期心功能及心肌细胞损害的监测价值。方法以同期正常妊娠期妇女(46例)、妊娠期高血压疾病(HDCP)妇女(90例)及正常非孕妇女(40例)为研究对象。分别采用电化学发光免疫分析(ECLIA)法及双抗体夹心酶联免疫(ELISA)一步法,检测血清NT-proBNP和h-FABP水平。结果正常孕妇组及HDCP组血清NT-proBNP和h-FABP水平均显著高于正常非孕组(P<0.01),HDCP组血清NT-proBNP和h-FABP水平均显著高于正常孕妇组(P<0.01);正常孕妇组及HDCP组血清NT-proBNP阳性率(55.15%)显著低于血清h-FABP的阳性率(82.35%)(P<0.01),且两者具有相关一致性;妊娠期妇女血清h-FABP水平与NT-proBNP呈显著正相关(r=0.693,P<0.01),相关性良好。结论妊娠期妇女血清NT-proBNP和h-FABP水平显著升高,且具有相关性,联合检测其水平可及时了解并发早期心脏功能及心肌细胞损害情况,对指导治疗及改善预后具有重要意义。Objective To investigate the clinical significance of N-terminal pro-brain B-type natriuretic peptides（NT-proBNP） and heart-type fatty acid binding protein（h-FABP） in early injury monitoring of cardiac function and myocardial cells in pregnant women.Methods The levels of NT-proBNP and h-FABP were detected in 46 normal pregnant women,90 women with hypertensive disorders complicating pregnancy（HDCP） and 40 non-pregnant women using electrochemiluminescence immunoassay（ECLIA） and double antibody enzyme-linked immunosorbent assay（ELISA） respectively.Results The NT-proBNP and h-FABP levels in normal pregnant women and HDCP were significantly higher than non-pregnant women（P0.01）.NT-proBNP and h-FABP increased significantly in HDCP when compared to normal pregnant women（P0.01）.In normal pregnant women and HDCP,the positive rate of NT-proBNP（55.15%） was significantly lower than the rate of h-FABP（82.35%）（P0.01）.In pregnant women,h-FABP was positively correlated with NT-proBNP（r=0.693,P0.01）.Conclusions The serum NT-proBNP and h-FABP levels in pregnancy women increased significantly.We should monitor their changes to find early injury of cardiac function and myocardial cells.

关 键 词：妊娠期妇女 N末端B型钠尿肽原 心脏型脂肪酸结合蛋白 心功能损伤 心肌细胞损害 临床价值 

分 类 号：R714.24[医药卫生—妇产科学] R446.112[医药卫生—临床医学]