金属硫蛋白对轻度铅中毒儿童的干预效应  

Intervention effects of metallothionein on mild lead poisoning in children

作　　者：蒲昭霞[1] 孙慧琳[1] 王国毅[1] 高瑞宁[1] 

机构地区：[1]成都军区机关医院儿科,四川成都610011

出　　处：《检验医学与临床》2013年第A01期16-17,共2页Laboratory Medicine and Clinic

摘　　要：目的评价金属硫蛋白制剂对铅中毒儿童的干预效应。方法选择门诊体检血铅大于100μg／L的儿童，随机分为干预组和对照组，干预组加用金属硫蛋白口服制剂，两组其余条件一致，3个月后复查两组血铅值。结果两组干预前血铅值比较差异无统计学意义（P〉0．05），干预后干预组血铅值较对照组明显降低，差异有统计学意义（P〈0．01）；对照组干预后血铅值较干预前下降，差异有统计学意义（P〈0．05）。结论口服金属硫蛋白制剂，可以明显降低血铅，值得临床推广应用。Objective To evaluate the intervention effects of metallothionein on mild lead poisoning in chil dren. Methods Children with blood level of lead more than 100 μg/L were divided randomly into intervention group and control group. Except taking metallothionein preparations, children of the two groups were treated for the same way. 3 months later, blood lead levels were measured again. Results There was no significantly statistical difference of blood lead level between the two groups before intervention （P〉0.05）, but there was significant difference be- tween the two groups after intervention （P〈0.01）, and blood lead level were significantly decreased in intervention group after intervention （P〈0.05）. Conclusion Taking metallothionein preparations could obviously reduce blood lead level in children with mild lead poisoning.

关 键 词：金属硫蛋白 铅中毒 儿童 

分 类 号：R995[医药卫生—毒理学]