乙型肝炎中丁型肝炎病毒重叠感染的血清学调查  

Serologicai investigation of superinfection of hepatitis D virus in patients with hepatitis B

作　　者：方志红[1] 金一鸣[2] 

机构地区：[1]江苏省苏州市中医医院检验科,215006 [2]江苏省苏州市中心血站,215004

出　　处：《检验医学与临床》2013年第A01期17-19,共3页Laboratory Medicine and Clinic

摘　　要：目的了解乙型肝炎患者中丁型肝炎病毒（HDV）的感染情况，为今后治疗工作提供科学依据。方法对264例乙型肝炎患者样本，利用酶联免疫吸附试验（ELISA）技术，检测HBV和HDV的免疫血清标志物（HBV：HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc；HDV：HDVIgM和IgG抗体），统计分析HDV感染的阳性率。结果统计学分析显示，264例样本HDV感染率为8．33％，其中HBV复制活跃组HDV感染率为3．41％，较HBV复制缓慢组HDV感染率（18．18％）明显低，差异有统计学意义（P〈0．01）。结论乙型肝炎患者容易重叠感染丁型肝炎病毒，HBV重叠感染HDV后，HDV的复制会抑制HBV的复制和表达。Objective To understand the infection status of hepatitis D virus （HDV） in hepatitis B patients to provide scientific basis for future treatment. Methods 264 cases of hepatitis 13 patient samples were detected for serum markers of hepatitis B virus （HBV） and HDV, including HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc, HDV IgM and IgG antibody, by using enzyme-linked immunosorbent assay （ELISA）, and the positive rate of HDV infection was analyzed. Results Statistical analysis showed that HDV infection rate in 264 cases was 8.33~, and HDV infection rate in active replication of HBV group was 3.41%, which was significantly lower than HDV infection rate（18.18%） in slow replication of HBV group（P〈0.01）. Conclusion Hepatitis B patients might be vulnera- ble to superinfection with HDV. After superinfection, HBV replication and expression could be inhibited by HDV replication.

关 键 词：丁型肝炎病毒 乙型肝炎病毒 酶联免疫试验 血清病毒性肝炎标志物 

分 类 号：R512.6[医药卫生—内科学]