IL-8基因多态性与幽门螺旋杆菌易感性的相关研究  

Correlation between -251A/T polymorphism of IL-8 and the susceptibility of Helicobacter pylori

作　　者：王文文[1] 吴春媛[1] 赵蜀崖[1] 

机构地区：[1]海南省人民医院胃镜室,海南海口571100

出　　处：《海南医学》2013年第16期2344-2345,共2页Hainan Medical Journal

摘　　要：目的探讨白细胞介素-8(IL-8)-251A/T基因多态性与幽门螺旋杆菌易感性的关系。方法收集我院消化内科2009年1月至2011年6月间的幽门螺旋杆菌阳性的慢性胃炎患者共276例作为实验组,阴性患者301例作为对照组。利用PCR-RFLP技术检测基因多态性,利用统计学方法对数据进行分析。结果 AA、AT、TT三种基因型的检出例(率)在实验组中为45例(16.3%)、152例(55.1%)、79例(28.6%),对照组中为107例(35.5%)、146例(48.5%)、48例(15.9%),组间比较差异具有统计学意义(P<0.05)。等位基因A/T在实验组和对照组中的检出率分别为43.8%/56.2%和59.8%/40.2%,组间比较差异亦具有统计学意义(P<0.05)。结论白细胞介素-8基因-251A/T基因多态性与幽门螺旋杆菌的易感性具有密切关联,等位基因T可能是幽门螺旋杆菌感染的危险因素。Objective To investigate the correlation between 251A/T polymorphism of IL-8 and the susceptibility of Helicobacter pylori.Methods A total of 276 cases with Helicobacter pylori positive were chosen as the study group,and 301 cases with Helicobacter pylori negative as the control group.The gene polymorphism was detected by PCR-RFLP and the data were statistically analyzed.Results The cases （rate） of AA,AT,TT genotypes detected was 45 （16.3％）,152 （55％）,79 （28.7％） in the study group and 107 （35.5％）,146 （48.5％）,48 （15.9％） in the control group.Difference between the two groups has statistical significance （P＜0.05）.Alleles of A/T in the study group and the control group was 43.8％/56.2％ and 59.3％/40.7％,respectively,and the difference was statistically significant （P＜0.05）.Conclusion-251A/T polymorphism of IL-8 is closely related with the susceptibility of Helicobacter pylori,and the T allele may be the risk factors of Helicobacter pylori infection.

关 键 词：白细胞介素 幽门螺旋杆菌 基因多态性 

分 类 号：R378.2[医药卫生—病原生物学]