阿奇霉素缓释微丸体外释药影响因素考察  

Factors influencing in vitro release of azithromycin from Sustained-release pellets

作　　者：何盛江 张现涛 宋力[2] 焦豪妍 

机构地区：[1]广东省中药研究所,广州510520 [2]中国药科大学,南京210009

出　　处：《海峡药学》2013年第7期26-28,共3页Strait Pharmaceutical Journal

摘　　要：目的 考察影响阿奇霉素缓释微丸体外释药的各种因素,为阿奇霉素缓释制剂的研制提供实验依据。方法 选用微晶纤维素为空白丸芯,将阿奇霉素制成缓释微丸,通过测定体外释放度,考察EC粘度及增重、致孔剂用量、释放介质pH值对阿奇霉素缓释微丸体外释药速率的影响。结果 EC粘度、包衣增重、致孔剂用量、释放介质pH值对释药速率有显著影响。结论 选用适宜包衣材料及致孔剂,调节包衣增重,可制备具有理想释药行为的阿奇霉素缓释微丸。OBJECTIVE To investigate the impact of the in vitro release of azithromycin sustained-release pel- lets of various factors,and provide experimental basis for the development of azithromyein sustained-release formula- tions. METHODS Azithromyein was made to sustained-release pellets,with microerystalline cellulose as blank pill core. The in vitro release was measured to investigate the effect of EC viscosity, weight gain and poreforming agents dosage and the release medium pH on release rate in vitro. RESULTS EC viscosity, weight gain, pore-forming a- able coating material and pore-forming agents, adjust coating weight can prepare the desired release behavior of az- ithromyein sustained-release pellets.

关 键 词：阿奇霉素 体外 释药速率 

分 类 号：TQ460.4[化学工程—制药化工]