通脉降脂片质量标准分析  

The quality standard analysis of Tongmai Jiangzhi Tablets

作　　者：罗珍妹[1] 陈惠玲[1] 黄惠琼[1] 李玲[1] 

机构地区：[1]福建省厦门市药品检验所,厦门361012

出　　处：《海峡药学》2013年第7期100-104,共5页Strait Pharmaceutical Journal

基　　金：厦门重大科技平台项目课题编号:3502Z20121035

摘　　要：目的建立通脉降脂片质量标准。方法采用TLC法对处方中笔管草、川芎、荷叶、三七进行定性鉴别,采用HPLC法测定处方中三七的三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1的含量。结果 TLC鉴别笔管草、川芎、荷叶、三七斑点清晰,专属性强,空白对照无干扰;测定三七中三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1平均回收率分别为:98.9%、100.4%、101.7%,RSD分别为1.27%、0.70%、0.74%,(n=9)。结论本方法结果准确,重现性良好,可用于通脉降脂片的药品质量控制。OBJECTIVE To determine the quality standard analysis of Tongmai Jiangzhi Tablets. METHODS Seorzonera alhicaulis Bunge, Rhizoma ehuanxiong, Folium Nelumbinis, Notoginseng Radix et Rhizoma in Tongrnai Jiangzhi Tablets were identified by TLC. The contents of notoginsenoside R1, ginsenoside Rgl, ginsenoside Rb1 in No- toginseng Radix et B.hizoma were determined by HPLC. RESULTS The qualitative identification with TLC were specific. The average recoveries were 98. 9%, 100. 4% and 101.7% respectively in the determination of notoginsen- oside R1 ,ginsenoside Rg1 , ginsenoside Rb1 in Notoginseng Radix et Pdaizoma. The RSD were 1.27% ,0. 70% and 0. 74%, （ n = 9） respectively. CONCLUSIONThe result demonstrates that the method is accurate and has well re- producibility, so it ean be used for the quality standard control of Tongmai Jiangzhi Tablets.

关 键 词：通脉降脂片 三七皂苷R1、人参皂苷Rg1、人参皂苷Rb1 TLC HPLC 

分 类 号：R927.11[医药卫生—药学]