结核分枝杆菌的耐药性研究  

RESEARCH ON THE DRUG - RESISTANT OF Mycobacterium tuberculosis

作　　者：花春玲[1] 孙晓穗[1] 平静珍[1] 王艳霞[1] 

机构地区：[1]首都医科大学附属北京胸科医院,北京101149

出　　处：《中国消毒学杂志》2013年第7期626-627,共2页Chinese Journal of Disinfection

摘　　要：目的研究临床分离结核分枝杆菌耐药性,为科学选择抗结核药物提供依据。方法采用病人标本分离培养和药敏试验方法,对617例结核分枝杆菌临床分离株进行耐药性调查。结果本医院2011年度从住院结核患者痰标本中分离到617株结核分枝杆菌,均进行了临床常用抗结核药物敏感试验。所分离的临床株结核分枝杆菌对异烟肼和利福喷叮的耐药率均超过31%;对利福平和链霉素的耐药率超过27%,对利福布叮、丁胺卡那霉素耐药率超过15%。结论该医院临床分离的结核分枝杆菌耐药率处于较高的水平,提示临床应根据药敏试验结果选择抗结核药物,控制耐药结核菌株的产生。Objective To investigate the drug - resistant of Mycobacterium tuberculosis （TB） isolated strains so as to guide the choice of anti - TB drugs. Methods Totally 617 isolated strains of M. tuberculosis were collected from hospitals and were cultured to detect the drug- resistant M. tuberculosis. Results Among the 617 isolated strains from sputum of hospitals in 2011, more than 31% were resistant to Isoniazid and Rifapentine, more than 27% were resistant to Rifampicin and Streptomycin and more than 15% were resistant to Rifabutin and Amikacin. Conclusion The hospitals drug- resist- ant rate of M. tuberculosis is at a high level. Selection of anti - TB drugs should be based on susceptibility testing results to control the generation of drug - resistant stains of M. tuberculosis.

关 键 词：结核分枝杆菌 抗结核药物 耐药性 监测 

分 类 号：R378[医药卫生—病原生物学]