炎症因子与2型糖尿病合并代谢综合征患者亚临床动脉粥样硬化的关系  

Correlation between inflammatory factors and subclinical atherosclerosis in type 2 diabetic patients with metabolic syndrome

作　　者：秦映芬[1] 黄迪迪[1] 周嘉[1] 钱家乐[1] 蒋婵[1] 

机构地区：[1]广西医科大学第一附属医院内分泌科,南宁530021

出　　处：《中华内分泌代谢杂志》2013年第7期592-594,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：广西壮族自治区教育厅课题（桂教200710LX065）;广西研究生教育创新计划（2009105981002M206）

摘　　要：用ELISA法检测甘露糖结合凝集素（mannose—bindinglectin，MBL）、纤溶酶原激活物抑制物-1（PAI．1）及超敏C反应蛋白（hs—CRP）水平，探讨其与2型糖尿病合并代谢综合征（MS）患者亚临床动脉粥样硬化（As）的关系。亚临床As组hs—CRP升高（P〈0．01），MBL无统计学差异（P〉0．05），PAI-1仅在合并Ms的患者中显著升高（P〈0．01）；不考虑亚临床As因素，2型糖尿病合并Ms患者MBL降低，hs—CRP、PAI-1升高（均P〈O．01）。炎症因子MBI，hs—CRP、PAI-1参与了2型糖尿病合并Ms患者亚临床As的发展。ELISA technique was employed to determine the concentration of mannose-binding lectin （ MBL）, plasminogen activator inhibitor-1 （ PAI-1 ）, and high sensitive-C reactive protein （ hs-CRP）, hs-CRP level in patients with subclinical atherosclerosis was significantly higher P〈0. 01 ）, MBL level was of no significant difference （ P〉0.05 ） ; PAI-1 was significantly higher （ P〈0.01 ） only in those with metabolic syndrome （ MS ）. Taking no account of subclinical atherosclerosis, MBL of diabetic patients with MS was significantly lower while hs-CRP and PAI-1 were significantly higher （ P 〈 0. 01 ）. Inflammatory factors MBL, hs-CRP, and PAI-1 involved in the subclinical atherosclerosis development in the type 2 diabetic patients with MS.

关 键 词：糖尿病 2型 代谢综合征 亚临床动脉粥样硬化 甘露糖结合凝集素 超敏C反应蛋白 纤溶酶原激活物抑制物一1 

分 类 号：R587.1[医药卫生—内分泌]