二甲双胍对2型糖尿病患者血清癌胚抗原水平的影响  

Effect of metformin on serum carcino embryonic antigen levels in type 2 diabetic patients

作　　者：张丹丹[1] 刘芳[1] 唐峻岭[1] 郑泰山[1] 陆惠娟[1] 谢君[1] 卢逢娣[1] 包玉倩[1] 贾伟平[1] 

机构地区：[1]上海交通大学附属第六人民医院内分泌代谢科,上海市糖尿病临床医学中心,上海市糖尿病研究所,上海市糖尿病重点实验室,200233

出　　处：《中华内分泌代谢杂志》2013年第7期594-597,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81070650）

摘　　要：将493例2型糖尿病患者按照是否服用二甲双胍分为双胍组和非双胍组，比较2组患者血清癌胚抗原（CEA）水平和生化特征，采用Pearson或Spearman相关分析和多元逐步回归分析影响CEA水平的因素。结果显示双胍组血清CEA水平明显低于非双胍组[（2．57±1．47对3．09±1．79）mmot／L，P〈0．01]；女性血清CEA水平明显低于男性[（2．48±1。41对3．12±1．78）mmo]／L，P〈0．01]，绝经后高于绝经前（P〈0．05）。Spearman相关分析显示CEA与HbA。糖化血清白蛋白、应用二甲双胍、性别和睾酮呈显著相关（P〈0．01）。多元逐步回归分析显示HbA，（P〈0．01）、二甲双胍（P=0．019）、性别（P〈0．01）和睾酮（P〈0．01）是CEA的独立影响因素。提示2型糖尿病患者血清CEA水平存在性别差异．二甲双胍可降低2型糖尿病患者，尤其是女性患者的血清CEA水平。Serum carcino embryonic antigen （CEA） levels were measured and compared in 493 patients with type 2 diabetes including one group receiving, and another group without metformin treatment. Assoeiations between CEA and other variables were assessed with Spearman or Pearson correlation analysis and multiple stepwise regression analysis. The results showed that CEA level in metformin group was significantly lower than that in nonmetformim group [ （ 2.57 ±1.47 vs 3.09 ± 1.79 ） mmol/L, P〈0. 01 ] ; CEA level in females was significantly lower than that of males [ （ 2.48 ±1.41 vs 3.12± 1. 78 ） mmol/L, P〈0.01 ] ; CEA level in postmenopausal women was significantly higher than that in premenopausal women （ P〈0.05 ）. The correlation analysis showed that serum CEA levels were significantly associated with HbAc, glycated albumin, metformin, gender, and testosterone （P 〈 0.01 ）. Muhiple stepwise regression analysis further revealed that HbAlc（P〈0.01 ）, metformin administration （P= 0.019 ） , gender （ P〈 0.01 ） , and T levels （ P 〈 0.01 ） were independent influencing factors of CEA concentrations. These results suggest that there is gender difference in serum CEA levels in type 2 diabetic patients. Metformin mayreduce serum CEA levels in type 2 diabetic patients, especially in the female patients.

关 键 词：糖尿病 2型 二甲双胍 癌胚抗原 性别 

分 类 号：R587.1[医药卫生—内分泌]