酞菁在光动力治疗中的应用  

Phthalocyanine Based Photosensitizers for Photodynamic Therapy

作　　者：丁兰兰[1] 栾立强[1] 施佳伟[1] 刘伟[1] 

机构地区：[1]山东大学晶体材料国家重点实验室,济南250100

出　　处：《无机化学学报》2013年第8期1591-1598,共8页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金(No.21071090);山东大学自主创新基金(No.2012JC013)资助项目

摘　　要：光动力治疗因具有低毒、副作用小、抗癌广谱、高选择性等优势,正吸引着人们越来越多的关注。提高光敏剂的选择性和光毒性已经成为研究的热点。本文简单介绍了光敏剂的发展历程,并对酞菁类第三代光动力治疗光敏剂的最新研究进展进行了论述。Photodynamic therapy （PDT） is a clinically approved procedure. Due to its minimal normal tissue toxicity, negligible side effects and high selectivity, it has emerged as an efficient treatment method for many kinds of cancers. Recently, significant effort has been devoted to enhance its selectivity and phototoxicity toward malignant tissues. This review summarizes the recent research of photosensitizers, especially focuses on the progress of the third generation photosensitizers based on phthalocyanines.

关 键 词：光动力治疗 光敏剂 酞菁 靶向 

分 类 号：O61[理学—无机化学] R730.5[理学—化学]