针灸治疗膝骨关节炎的应用效果及机制  

Effect and mechanism of acupuncture in the treatment of knee osteoarthritis

作　　者：周景辉[1] 吴耀持[1] 谢艳艳[1] 张峻峰[1] 黄承飞[1] 孙懿君[1] 

机构地区：[1]上海交通大学附属第六人民医院针推伤科,上海市200233

出　　处：《中国组织工程研究》2013年第28期5255-5260,共6页Chinese Journal of Tissue Engineering Research

基　　金：上海交通大学附属第六人民医院院内课题支出;课题编号"院内-116"~~

摘　　要：背景:研究表明针灸结合中药治疗膝骨关节炎具有一定的效果。目的:探讨针灸结合中药治疗膝骨关节炎的机制及效果评价。方法:建立膝骨关节炎动物模型,检测相关因子基质金属蛋白酶3、转化生长因子β、白细胞介素1β和肿瘤坏死因子α表达含量的变化;对应用针灸联合药物治疗膝骨关节炎的患者进行随访观察,针刺主穴结合配穴,中药服用或外敷熏蒸,观察膝关节活动功能恢复情况,明确应用针灸结合中药干预治疗的效果。结果与结论:针灸治疗能够通过降低基质金属蛋白酶3、转化生长因子β、白细胞介素1β和肿瘤坏死因子α的含量,延缓膝关节软骨的破坏,改善膝关节功能,从而发挥对膝骨性关节炎的治疗作用。膝骨关节炎的患者应用针灸结合中药治疗后,获得较好的效果,治疗有效率高达90%以上,并且与单一应用透明质酸钠或针灸治疗相比较,针灸结合中药治疗的有效率更高,治疗效果更好。METHODS： The animal models of knee osteoarthritis were established to detect the expression levels of related factors, including matrix metalloproteinase 3, transforming growth factor β, interleukin-lβ and tumor necrosis factor-e. The knee osteoarthritis patients treated with acupuncture combined with Chinese medicine were followed-up, and the patients received acupuncture in the main points and the adjunct points, as well as the Chinese medicine administration and the external application and fumigation. Then, the active function recovery of the knee joint was observed to identify the effect of acupuncture combined with Chinese medicine. RESUTLS AND CONCLUSION： Acupuncture can delay the destruction of knee joint articular cartilage and improve the knee function through decreasing the contents of matrix metalloproteinase 3, transforming growth factor β, interleukin-lβ and tumor necrosis factor-a, thus playing the treatment effect on knee osteoarthritis. The knee osteoarthritis patients treated with acupuncture combined with Chinese medicine can obtain better effect, and the treatment efficiency is more than 90%. Compared with the single application of sodium hyaluronate or acupuncture treatment, acupuncture combined with Chinese medicine has higher treatment efficiency and better treatment effect.

关 键 词：组织构建 组织构建学术探讨 针灸 中药 膝骨关节炎 关节腔 滑膜 透明质酸钠 基质金属蛋白酶3 转化生长因子β 白细胞介素1 肿瘤坏死因子 其他基金 

分 类 号：R318[医药卫生—生物医学工程]