钛种植体表面改性策略及对骨整合的影响  

Titanium implants: Strategies on surface modification and effect on osseointegration

作　　者：李莺[1] 李长义[1] 

机构地区：[1]天津医科大学口腔医院,天津市300070

出　　处：《中国组织工程研究》2013年第29期5395-5402,共8页Chinese Journal of Tissue Engineering Research

基　　金：天津市高等学校科技发展基金计划项目(20120126)~~

摘　　要：背景:纯钛因具有优良的生物相容性、机械性能和与骨组织相近的弹性模量等被广泛应用于口腔种植领域。目的:综述近年来钛金属种植体材料表面物理改性、化学改性和生物化学改性策略的研究进展。方法:以"titanium,implant,surfac emodification,osseointegration"为检索词,检索PubMed数据库,以"钛,种植体,表面改性,骨整合"为检索词,检索中国知网数据库,限定时间范围为2007年1月至2013年2月。文献检索语种为英文和中文。纳入内容与钛种植体表面改性方法及其对骨整合影响密切相关的文献,排除重复文献。结果与结论:计算机初检得到199篇文献,根据纳入排除标准,对其中76篇文献进行分析。钛种植体本身是生物惰性材料,通过表面改性对钛金属表面进行活化处理,使之具有生物功能性,与骨组织形成早期骨整合,是国内外口腔种植材料研究的热点问题。物理改性、化学改性和生物化学改性可缩短钛种植体种植周期,获得早期骨整合和更高的结合强度。今后的发展趋势是将多种改性方法有机结合,从分子水平深入研究钛金属材料表面与机体细胞和组织之间的界面分子作用机制,完善种植体的表面改性技术,实现种植体和骨组织的早期和更加稳定的骨整合。BACKGROUND：Titanium has been widely used in dental implantation because of its good biocompatibility, mechanical properties and its similar elastic modulus to the bone. OBJECTIVE：To summarize three strategies for surface modification of titanium implants：physical modification, chemical modification and biochemical modification. METHODS：PubMed and CNKI databases were searched for articles published from January 2007 to February 2013, and the key words were“titanium, implant, surface modification, osseointegration”in English and Chinese, respectively. Articles which are closely related to titanium implant surface modification and osseointegration were included, and repetitive articles were removed. RESULTS AND CONCLUSION：After preliminary search, 199 articles were found. According to the inclusion criteria and exclusion criteria, 76 articles were further analyzed. Titanium implant is a bioinert material, and thus the researchers focus on surface modification to activate the titanium implant so as to possess biological function and achieve early osseointegration. Implant surface modification strategies include three perspectives：physical modification, chemical modification and biochemical modification which can shorten the period of implant therapy and achieve early osseointegration and higher binding strength. The future research trend is to combine three strategies and to further explore the molecular basis of mechanism at the interface between implant and organism cel and the tissue in order to use better surface modification technology to fulfil the early and more stable osseointegration between the implant and bone tissue.

关 键 词：生物材料 生物材料综述 组织工程骨材料 口腔种植材料 钛 种植体 表面改性 骨整合 物理改性 化学改性 生物化学改性 省级基金 

分 类 号：R318[医药卫生—生物医学工程]