人工硬脑膜材料在神经外科手术中的应用:附100例分析  

Artificial dura materials in neurosurgical procedures: An analysis of 100 cases

作　　者：韦鹏翔[1] 李丹青[1] 周玉嘉[1] 刘佳霖[1] 王雷[1] 

机构地区：[1]北京中医药大学东方医院神经外科,北京市100078

出　　处：《中国组织工程研究》2013年第29期5415-5420,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:对于脑膜缺损患者可以通过人工硬脑膜材料结合神经外科技术进行修复,保护脑组织的完整。目的:分析各种人工硬脑膜材料的生物相容性及应用可行性。方法:按照硬脑膜材料的不同来源进行分类,分析各种硬脑膜材料的生物相容性和可行性,以及各种材料的优缺点,通过材料复钙试验及溶血试验的结果分析材料的抗凝特性和溶血性。结合北京中医药大学东方医院神经外科100例胶原蛋白膜修补后观察。结果与结论:硬脑膜修复的材料主要有自体材料、同种异体材料、异种材料、人工合成材料以及天然材料,每种材料都各自不同的优势和不足。脑膜缺损修补的并发症有脑脊液漏、假性脑膜膨出、感染、蛛网膜炎等。人工硬脑膜材料目前还有许多问题需要解决,新型生物硬脑膜材料和可吸收材料是未来的研究方向。BACKGROUND：The meningeal defect patients can be treated with artificial dural materials combined neurosurgical techniques which can protect the integrity of brain tissue. OBJECTIVE：To analyze the biocompatibility and application feasibility of various artificial dura mater materials. METHODS：The artificial dura materials were classified according to the different sources, and the biocompatible and application feasibility of various artificial dura mater materials were analyzed, as wel as the advantages and disadvantages of various materials. The anticoagulant and hemolytic properties of the materials were analyzed through recalcification test and hemolysis test. 100 patients receiving col agen membrane repair selected from Department of Neurosurgery, Dongfang Hospital of Beijing University of Chinese Medicine were observed. RESULTS AND CONCLUSION：The dural repair materials mainly include autologous material, al ograft materials, dissimilar materials, synthetic materials and natural materials. Each kind of material has its advantages and disadvantages. Meningeal defect complications include cerebrospinal fluid leakage, pseudo meninges, infection and arachnoiditis. There are many problems of artificial dural materials to be solved, and the novel biological dural materials and absorbable materials are the direction of dural material research.

关 键 词：生物材料 生物材料学术探讨 硬脑膜材料 生物相容性 脑损伤 膨聚四氟乙烯 壳聚糖 牛心包 丝素膜 脑脊液漏 粘连 

分 类 号：R318[医药卫生—生物医学工程]