外阴阴道念珠菌病、复发性外阴阴道念珠菌病及健康人群甘露糖结合凝集素水平的分析研究  

The study of the lectin level in healthy population,vulvovaginal candidiasis (VVC) and recurrent vulvovaginal candidiasis (RVVC) groups

作　　者：刘格[1] 王薇华[1] 孙静[1] 马雪枫[1] 陈爱群[1] 

机构地区：[1]深圳市宝安区妇幼保健院,深圳518000

出　　处：《中国真菌学杂志》2013年第3期160-162,168,共4页Chinese Journal of Mycology

基　　金：深圳市宝安区科技局课题(2010703)

摘　　要：目的观察健康人群、外阴阴道念珠菌病(VVC)和复发性外阴阴道念珠菌病(RVVC)的甘露糖结合凝集素水平。方法收集健康人群、VVC和RVVC病例,给予规范化治疗,观察治疗前、后各组MBL水平的变化,并进行随访。结果发现各组的MBL水平VVC组>RVVC组>健康组,但各组之间及各组本身治疗前后的MBL差异无显著性意义(P>0.05)。治疗后VVC组复发者5例,占14%,RVVC组复发者13例,达到48%,两组复发者与未复发者的MBL水平,经t检验无显著性差异(P>0.05)。结论 MBL的水平在VVC患者中的水平高于RVVC患者,两者的复发率基本与既往文献报道一致,对于VVC患者来说,MBL水平高于0.8 ng/mL似乎患RVVC的风险稍小些。Objective To value the levels of mannose lectin in healthy population, vulvovaginal candidiasis （VVC） and recur- rent vulvovaginal candidiasis （RVVC） groups. Method All the VVC and RVVC cases were given standardized treatment. Compared with heahhy population, the MBL levels before and after treatment were observed in these two groups. Results The MBL levels of vvc group, RVVC group, healthy group were arranged from high to low numerically. But there was no significant difference among groups or within every group before and after treatment （ P 〉 0.05 ） . There were 14% （5/43） cases of recurrence in VVC group and 48% （13/30） eases of recurrence in RVVC group, respectively. There was no significant differeene of recurrence between VVC and RVVC groups （ P 〉 0.05）. Conclusion The level of MBL is higher numerically in VVC group than the level in RVVC group. The recurrence in both groups is eonsistet with the previously literature. The VVC patients with MBL level higer than 0.8 ng/ mL seems to have lower risk of suffering RVVC.

关 键 词：外阴阴道念珠菌病 甘露糖结合凝集素 复发 

分 类 号：R756.2[医药卫生—皮肤病学与性病学]