萘替芬酮康唑乳膏治疗股癣疗效观察  

Treatment effect of naftifine/ketoconazole cream to tinea cruris

作　　者：刘磊[1] 李振鲁[2] 

机构地区：[1]河南省信阳职业技术学院附属医院皮肤科,信阳464000 [2]河南省人民医院皮肤科,郑州450003

出　　处：《中国真菌学杂志》2013年第3期176-178,共3页Chinese Journal of Mycology

摘　　要：目的观察萘替芬酮康唑乳膏治疗股癣疗效和安全性。方法将160例患者随机分为治疗组和对照组,治疗组外用萘替芬酮康唑乳膏;对照组外用硝酸咪康唑乳膏,均早晚各涂一次。用药2周及停药3周后分别进行临床疗效和真菌学疗效评价。结果治疗2周时治疗组有效率为92.50%,而对照组有效率为76.25%,两组间差异有统计学意义(P<0.05)。治疗2周时真菌清除率治疗组97.50%,对照组87.50%,两组间差异有统计学意义(P<0.05)。停药3周时治疗组有效率为96.25%,对照组有效率为75.00%,两组间差异有统计学意义(P<0.05)。停药3周时真菌学清除率治疗组97.50%,对照组85.00%,两组间差异有统计学意义(P<0.05)。无明显不良反应发生。结论萘替芬酮康唑乳膏治疗股癣安全有效。Objective To observe the clinical efficacy in the treatment of tinea cruris by naftifine/ketoconazole cream. Methods One hundred and sixty patients with tinea versicolor were randomly divided into trial group and control group. Naftifine/ketoconazole cream were applied in the trial group. Miconazole nitrate cream were applied in the control group. Both were used in the morning and evening. Clinical and mycological therapeutic effects were evaluated in 2 weeks of treatment and in 3 weeks of drug withdrawal. Results The effective rates in the treatment group and control group were 92.5% and 76.25% respectively,there was sig- nificant difference between the two groups （ P 〈 0.05 ） . Fungs clearance rate of the treatment group was 97.50% whereas control group was 87.5% at the end of 2 weeks treatment. There was significant difference between the two groups （ P 〈 0.05）. The effective rates in the treatment group and control group were 96.25% and 75.00% respectively,there was significant difference between the two groups （ P 〈 0.05 ）. Fungs clearance rate of the treatment group was 97.50% whereas control group was 85.00% at discontinued 3 weeks. There was significant difference between the two groups （ P 〈 0.05 ）. No obvious adverse reaction. Conclusion Naflifine/ketoconazole cream in treatment of tinea cruris is effect and safe.

关 键 词：萘替芬酮康唑乳膏 股癣 疗效观察 

分 类 号：R756.2[医药卫生—皮肤病学与性病学]