维持性血液透析患者不宁腿综合征的横断面研究  

A cross-sectional study of restless legs syndrome in maintenance hemodialysis patients

作　　者：肖成根[1] 梁馨苓[2] 李锐钊[1] 蔡璐[1] 许德珍[2] 

机构地区：[1]南方医科大学,广州510515 [2]广东省人民医院肾内科

出　　处：《中华内科杂志》2013年第8期672-674,共3页Chinese Journal of Internal Medicine

基　　金：广东省科技计划项目（20118031300007）

摘　　要：【摘要】目的了解维持性血液透析患者中不宁腿综合征（restlesslegssyndrome，RLS）的发病率及其影响因素。方法入选2012年9月1—30日在广东省人民医院血液净化中心行维持性血液透析的375例患者，收集相关实验室和透析指标数据，应用多元logistic回归分析对相关危险因素进行统计分析。结果RLS的发病率为13．3％，严重程度评分为（18．69±0．95）分，多元logistic回归分析显示无尿（OR0．292，95％C10．114～0．750）和B2微球蛋白升高（OR1．023，95％CI1．003～1．044）是维持性血液透析患者发生RLS的危险因素，而体重指数、血红蛋白、血清铁、甲状旁腺素等与RLS无相关性。结论维持性血液透析患者RLS发病率高，其发生危险因素为无尿和B：微球蛋白升高，故保存残余肾功能，提高透析充分性，特别是清除中分子毒素，可降低不宁腿的发生率进而改善透析患者的生活质量。Objective To explore the incidence and possible risk factors of restless legs syndrome （RLS） in the maintenance hemodialysis patients. Methods A total of 375 maintenance hemodialysis patients were enrolled in this study from September 1 to 30 in 2012. The diagnosis and assessment of severity were based on the International Restless Leg Syndrome Study Group （IRLSSG） standard. The relevant laboratory parameters and dialysis indicators were collected, such as hemoglobin, serum ferritin, parathyroid hormone, blood flow and dialysis mode. The clinical data were analyzed by multivariate logistic regression method, Results The incidence of RLS was 13.3% with the severity score of 18.69 -＋ 0. 95. The logistic regression analysis showed that anuria （OR O. 292,95% CI 0. 114-0. 750） and J32 microglobulin（ OR 1. 023, 95%C1 1.003-1.044） were the risk factors for RLS in the maintenance hemodialysis patients, while hemoglobin, serum iron and parathyroid hormone were not correlated with RLS. Conclusions The incidence of RLS is high in the maintenance hemodialysis patients. The risk factors of RLS are anuria and ~2 microglobulin. Therefore, the preservation of residual renal function and the improvement of dialysis adequacy, especially the removal of the middle molecular weight toxins, may reduce the occurrence of RLS and improve the quality of life in the hemodialysis patients.

关 键 词：不宁腿综合征 肾透析 横断面研究 

分 类 号：R459.5[医药卫生—治疗学]