冠心病与妊娠相关血浆蛋白A的Meta分析  

Association Between Coronary Heart Disease and Pregnancy-associated Plasma Protein A: A Meta-analysis

作　　者：王银谦[1] 徐博[1] 张向阳[1] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,新疆乌鲁木齐市830054

出　　处：《中国动脉硬化杂志》2013年第7期644-649,共6页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨冠心病与妊娠相关血浆蛋白A(PAPP-A)的关系,指导临床工作。方法从中国期刊网全文数据库和Pubmed等外文专业数据库中收录的2001～2012年有关妊娠相关血浆蛋白A与冠心病相关分析文献中,纳入符合条件的文献,应用RevMan 5.0软件进行分析。结果本研究共纳入10项研究,包括1 091例研究对象。结果显示,稳定型心绞痛和PAPP-A水平的关系:95%CI为0.02、0.34(P=0.03);不稳定型心绞痛和PAPP-A水平的关系:95%CI为1.32、1.74(P<0.01);急性心肌梗死和PAPP-A水平的关系:95%CI为1.83、2.38(P<0.01);冠状动脉1支病变和PAPP-A水平的关系:95%CI为1.78、2.50(P<0.01);冠状动脉2支病变和PAPP-A水平的关系:95%CI为1.83、7.72(P<0.01);冠状动脉3支病变和PAPP-A水平的关系:95%CI为2.39、3.26(P<0.01)。结果表明冠心病及冠状动脉病变的支数与妊娠相关血浆蛋白A高度相关,均有统计学意义。结论冠心病及冠状动脉病变的支数均与妊娠相关血浆蛋白A有密切的关系。Aim To study the relationship between coronary heart disease and pregnancy-associated plasma protein A （PAPP-A） for guiding the clinical work. Methods The articles relating to the analysis of coronary heart disease and pregnancy-associated plasma protein A （PAPP-A） were studied from the China Journal Full-text Database and Pubmed professional foreign language database collected from 2001 to 2012. The right articles were chosen and analyzed with RevMan 5.0 software.Results This article encompasses 10 studies, including 1091 objects of study. The results show that： The relationship between the stable angina and PAPP-A levels is 95% CI 0.02, 0.34 （P=0.03） The relationship between unstable angina and PAPP-A levels is 95% CI 1.32, 1.74 （P〈0.01） The relationship between acute myocardial infarction and PAPP-A levels is 95% CI 1.83, 2.38 （P〈0.01）. And the relationship between one coronary artery disease and PAPP-A levels is 95% CI 1.78, 2.50 （P〈0.01） for two coronary arteries disease, it is 95% CI 1.83, 7.72 （P〈0.01） for three coronary arteries disease, it is 95% CI 2.39, 3.26 （P〈0.01）. According to all these results of the study, it shows that the mutation quantity of coronary heart disease and coronary artery is highly connected with pregnancy associated plasma protein-A. And its of significance to statistics study. Conclusion Through the study, it shows that the quantity of coronary heart disease and coronary artery lesion has close relationships with pregnancy-associated plasma protein A.

关 键 词：冠心病 妊娠相关血浆蛋白A META分析 

分 类 号：R541[医药卫生—心血管疾病]