Catalyst-free alkylation of aminopyrazole by isatin in water  

作　　者：YANG JinMing WU Lin FANG Dong CAO Jian JI ShunJun 

机构地区：[1]Key Laboratory of Coastal Wetland Bioresources and Environmental Protection of Jiangsu Province, College of Chemistry and Chemical Engineering, Yancheng Teachers University [2]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University

出　　处：《Chinese Science Bulletin》2013年第24期2944-2949,共6页

基　　金：partially supported by the Natural Science Foundation of Jiangsu Province (BK2011422);the Natural Science Key Basic Research of Jiangsu Province for Higher Education (05KJD150251);the Key Laboratory of Organic Synthesis of Jiangsu Province (KJS1112);the Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection (JLCBE06008)

摘　　要：Reactions of isatins with 5-aminopyrazole afforded the 3-(5-aminopyrazol-4-yl)-3-hydroxy-2-oxindolines in good to excellent yields in refluxing water. No catalysts were required in the process. The new method exhibited the characteristics including green process, high yields, easy operation, and mild reaction conditions.Reactions of isatins with 5-aminopyrazole afforded the 3-（5-aminopyrazol-4-yl）-3-hydroxy-2-oxindolines in good to excellent yields in refluxing water. No catalysts were required in the process. The new method exhibited the characteristics including green process, high yields, easy operation, and mild reaction conditions.

关 键 词：无催化剂 氨基 烷基化 水 反应条件 绿色工艺 产量高 吡唑 

分 类 号：TQ203.2[化学工程—有机化工]