Discrimination of signal oscillations in the in vitro olfactory bulb with microelectrode array  

作　　者：CHEN QingMei DONG Qi HU Liang LING ShuCai YIN YiFei LIU QingJun WANG Ping 

机构地区：[1]Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University [2]Department of Biomedical Engineering, Jiangxi University of Traditional Chinese Medicine [3]Institute of Anatomy and Cell Biology, School of Medicine, Zhejiang University

出　　处：《Chinese Science Bulletin》2013年第24期3015-3018,共4页

基　　金：supported by the National Natural Science Foundation of China (81027003);the Research Fund for the Doctoral Program of Ministry of Education of China (20120101130011)

摘　　要：The aim of the present study was to investigate the electrophysiological characteristics of the different layers of the olfactory bulb (OB). We used an in vitro OB slice coupled onto a microelectrode array (MEA) for simultaneous detection of spontaneous activities of OB neurons at different sites. Different frequency oscillations dominated the different layers of the OB slice, and the gamma frequency oscillations mainly appeared in the glomerular layer. The waves consisted of negative, positive, and bidirectional spikes, and were distributed at the different layers of the OB slice. Thus, combination of the OB slice with MEA is a useful technique for identifying signal oscillations by multi-site synchronous measurement, and will allow further studies on olfactory information coding and processing function.The aim of the present study was to investigate the electrophysiological characteristics of the different layers of the olfactory bulb （OB）. We used an in vitro OB slice coupled onto a microelectrode array （MEA） for simultaneous detection of spontaneous activi- ties of OB neurons at different sites. Different frequency oscillations dominated the different layers of the OB slice, and the gam- ma frequency oscillations mainly appeared in the glomerular layer. The waves consisted of negative, positive, and bidirectional spikes, and were distributed at the different layers of the OB slice. Thus, combination of the OB slice with MEA is a useful tech- nique for identifying signal oscillations by multi-site synchronous measurement, and will allow further studies on olfactory in- formation coding and processing function.

关 键 词：微电极阵列 低频振荡 信号 嗅球 体外 电生理特性 自发活动 同时检测 

分 类 号：TN911.7[电子电信—通信与信息系统]