一种新型PEG衍生物水凝胶的温和制备方法与表征  

Characterized and prepared a new type of PEG derived hydrogel under mild condition

作　　者：彭坤[1,2] 王远亮[1] 孙姣霞[1] 张兵兵[1] 甘晓玲[2] 王易振[2] 

机构地区：[1]重庆大学生物工程学院生物材料与仿生工程研究中心,重庆400030 [2]重庆医药高等专科学校医学技术系,重庆401331

出　　处：《功能材料》2013年第14期2111-2114,共4页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(30870609);重庆市教委资助项目(KJ112501);重庆市卫生局资助项目(2012-2-257)

摘　　要：通过温和实验条件制备得到了一种新型PEG衍生物水凝胶。首先,通过将氨基封端的PEG与PMDA共聚,合成含有刚性片段苯酰亚胺环聚合物PAPI。在无催化剂温和条件下,该聚合物与BDA形成交联互穿微孔结构的功能化产物PAPI-BDA。采用傅里叶变换红外光谱(FT-IR)、核磁碳谱(13C NMR)、凝胶渗透色谱(GPC)、溶胀率实验和扫描电镜(SEM)对PAPI及PAPI-BDA进行了表征。结果表明实验成功获得了上述产物,其在水溶剂中具有显著溶胀效果,呈互穿性微孔结构,有望作为新型生物医用材料得到应用。PEG derived hydrogels were synthesized by a novel synthesis route under mild condition.First,we synthesized a soluble linear copolymer by amino-terminated polyethylene glycol ATPEG and pyromellitic dianhydride（PMDA）,named by p（ATPEG-co-PMDA）.The copolymer with imide rings on the main chain can be soluble in most of solvents.Then,the imide-rings of the copolymer were open by amino groups of butanediamine（BDA） under ambient condition to form cross-linking network.The cross-linking network can form in few minutes.The p（ATPEG-co-PMDA） and gels were characterized by 13C NMR and FT-IR.The gels swelled significantly in water,and co-continuous porous structure was observed by scanning electron microscopy.The ring-opening cross-linked reaction of p（ATPEG-co-PMDA） provided a simple,versatile approach to hydrogel network under mild condition without initiator,which have potential as biomaterials to apply in biomedical region.

关 键 词：聚乙二醇 水凝胶 互穿微孔结构 

分 类 号：TB324[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]