匹多莫德联合维生素AD滴剂佐治儿童反复呼吸道感染的疗效及对机体免疫功能的影响  

Effect of Pidotimod and Vitamin AD in the Treatment of Recurrent Respiratory Tract Infections and Its Influence on Immune Function

作　　者：黄莺[1] 

机构地区：[1]四川省成都市新都区中医院,四川成都610500

出　　处：《儿科药学杂志》2013年第7期16-18,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察匹多莫德联合维生素AD滴剂治疗儿童反复呼吸道感染的疗效及对机体免疫功能的影响。方法:选取90例符合入组标准的反复呼吸道感染患儿,按随机数字表法分为观察组和对照组各45例,对照组给予退热、祛痰、镇咳、抗感染等常规治疗,观察组在对照组治疗的基础上再给予匹多莫德联合维生素AD滴剂,随访6个月,治疗结束后观察患儿症状改善情况,检测T细胞亚群和免疫球蛋白,进行两组临床疗效评判,随访期间统计复发次数。结果:观察组显效率75.56%,总有效率91.11%,对照组显效率26.67%,总有效率80.00%,两组显效率、总有效率比较差异有统计学意义(P<0.01);随访期间平均复发次数观察组为(1.44±0.42)次,对照组为(6.02±1.05)次,两组比较差异有统计学意义(P<0.01);观察组和对照组的退热时间、咳嗽消失时间、扁桃体肿大消退时间、肺部啰音消失时间比较差异均有统计学意义(P<0.01);观察组治疗后T细胞亚群(CD3+、CD4+、CD8+)、免疫球蛋白(IgA、IgG、IgM)均较治疗前明显升高,差异有统计学意义;对照组治疗前后T细胞亚群、免疫球蛋白差异无统计学意义;治疗后观察组免疫球蛋白(IgG、IgA、IgM)、T细胞亚群(CD3+、CD4+、CD8+)均高于对照组,差异有统计学意义。结论:匹多莫德联合维生素AD滴剂治疗儿童反复呼吸道感染可显著增强患儿细胞免疫及体液免疫功能,能够缓解急性发作期的症状与体征,降低疾病的复发次数,值得临床推广使用。Objective： To observe the effect of pidotimod and vitamin AD on recurrent respiratory tract infections and its influence on immune function.Methods： Ninety children with recurrent respiratory tract infections met the inclusion criteria were randomly divided into an observation group and a control group equally.The control group was given conventional treatment,while the observation group was given pidotimod and vitamin AD on the basis of conventional treatment.After follow-up for six months,the symptoms were observed,Fcells subsets and immunoglobulin was detected,the clinical efficacy were evaluated,and recurrences times were counted.Results： The remarkable efficiency,total efficiency and recurrences frequency of the observation group and the control group were 75.56% vs 26.67%,91.11% vs 80.00%,（1.44±0.42） times vs（6.02±1.05） times,respectively.There were significant differences between the two groups（P0.01）.The time to defervesce,the disappearing time of coughing and pulmonary signs,and the recovery time of tonsil enlargement between the two groups were statistically different（P0.01）.T cell subsets（CD3＋,CD4＋,CD8＋） and immunoglobulin（IgA,IgG,IgM） of the observation group after treatment were significantly higher than those before treatment.These indicators of the control group were not changed significantly after treatment.T cell subsets（CD3＋,CD4＋,CD8＋） and immunoglobulin（IgA,IgG,IgM） of the observation group after treatment was significantly higher than those of the control group;there were significant differences.Conclusions： The therapy of pidotimod and vitamin AD can significantly enhance cellular immunity and humoral immunity,assist to alleviate the symptoms and signs of acute exacerbation,and reduce recurrence frequency,which is worthy of clinical use in the treatment of recurrent respiratory tract infections.

关 键 词：反复呼吸道感染 儿童 免疫调节剂 T细胞亚群 免疫球蛋白 

分 类 号：R725.6[医药卫生—儿科]