多索茶碱辅助治疗儿童哮喘急性发作临床研究  

The Clinical Efficacy of Doxofyiline in Children with Acute Attack of Asthma

作　　者：王斌[1] 周爱华[1] 陈静[1] 余春梅[1] 

机构地区：[1]重庆市第五人民医院,重庆400062

出　　处：《儿科药学杂志》2013年第7期24-26,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察多索茶碱治疗儿童支气管哮喘急性发作的临床疗效及安全性。方法:将支气管哮喘急性发作的145例患儿随机分为治疗组80例和对照组65例,治疗组在常规治疗的基础上给予多索茶碱6 mg/kg,对照组给予氨茶碱5 mg/kg,两药均于20～30 min内静脉滴注,观察喘息症状和肺部体征以及不良反应,测定最大呼气峰流速占预计值百分比(PEF-pred%)的变化。结果:治疗3 d后,两组患儿PEF-pred%变化比较差异有统计学意义(P<0.05);治疗组总有效率为96.3%,对照组为80.0%,两组比较差异有统计学意义(P<0.05)。治疗组不良反应发生率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:多索茶碱治疗儿童哮喘急性发作较氨茶碱更有效、安全,可作为哮喘急性发作辅助治疗方案的首选。Objective： To observe the clinical efficacy and safty of doxofyiline in children with acute attack of asthma.Methods： One hundred and forty-five acute attack of asthma children were involved and randomly divided into a control group and a treatment group.On the basis of therapy,eighty patients in the treatment group were treated for three days with doxofyiline 6 mg/kg by intravenous infusion within 20~30 minutes,once a day.In the control group,sixty five patients were treated with aminophylline 5 mg/kg.The symptoms,signs and adverse effects were observed pre-and post-treatment,and PEF-pred% was measured.Results： There was a significant difference of PEF-pred% pre-and post-treatment between the two groups（P〈0.05）.The total effective rate in the treatment group（including clinical control,excellence and improvement） was 96.3%,while in the control group it was 80.0%;the difference was statistically significant（P〈0.05）.The incidence rate of adverse effect in the treatment group was much lower than that in the control group,and the difference was statistically significant（P〈0.05）.Conclusions： Compare to aminophylline,doxofyiline in the treatment of acute attack of asthma in children was more effective and safe,and can be used as the first choice as additional treatment.

关 键 词：多索茶碱 氨茶碱 儿童 哮喘 急性发作 

分 类 号：R725.6[医药卫生—儿科]