盐酸加替沙星和氨溴索注射液配伍稳定性考察  

Compatible stability of gatifloxacin hydrochloride and ambroxol injection

作　　者：梁静[1] 洪倩[1] 

机构地区：[1]浙江医院药剂科,浙江310013

出　　处：《实用药物与临床》2013年第7期608-610,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的考察盐酸加替沙星和氨溴索在0.05%葡萄糖注射液中配伍的稳定性,为临床两药配伍的安全合理用药提供依据。方法采用高效液相色谱法,色谱条件:Kromasil C18色谱柱(150 mm×4.60 mm,5μm);磷酸二氢钠溶液(50 mmol/L,pH 3.7)∶乙腈(78∶22);流速1.0 mL/min;检测波长:254 nm;温度:25℃,分别测定盐酸加替沙星和氨溴索在配伍后0、1、2、4、6 h各时间点的含量、pH值,并观察其6 h内的外观及颜色。结果配伍液在6 h内均呈微黄色,澄明,肉眼未见沉淀和气泡,其在不同时间的质量浓度及pH值均未见明显变化。结论盐酸加替沙星和氨溴索在葡萄糖注射液中配伍6 h内稳定,但配伍液微粒检测及其他溶媒、其他温度下的稳定性尚需要进一步研究。Objective To examine the compatible stability of gatifloxacin hydrochloride and ambroxol injec- tion plus 0. 05 % glucose injection and provide the basis for the safe and rational use of the two drugs. Methods High performance liquid chromatography was used, chromatographic conditions ：kromasil C18 column （150 mm × 4. 60 mm,5 μm） ; sodium dihydrogen phosphate solution （ 50 mmol/L, pH 3.7 ） ： acetonitrile （ 78： 22 ） ; flow rate was 1.0 mL/min ; detective wavelength ：254 nm;temperature ：25 ℃. The content and pH of hydrochloric acid plus gatifloxacin and ambroxol within 6 h were measured, and the appearance and color within 6 h were observed. Results The mixed solution within 6 h showed slightly yellow, clear, no precipitate and the bubble with the naked eye,no significant change in the mass concentration and pH change at different time. Conclusion Hydrochloric acid and glucose gatifloxacin and ambr- oxol are compatible within 6h, but particle detection and compatibility on other solvents and other temperature still need further study.

关 键 词：加替沙星 氨溴索 配伍液 稳定性 

分 类 号：R942[医药卫生—药剂学]