转化生长因子β1、碱性成纤维细胞生长因子在下腔静脉隔膜阻塞型布-加综合征患者中的表达及意义  

Expression of transforming growth factor - β1, basic fibroblast growth factor in Budd -Chiari syndrome with membranous obstruction and its significance

作　　者：华浅近[1] 祖茂衡[1] 庄银苹[2] 滕飞[1] 胡琳[1] 

机构地区：[1]徐州医学院附属医院介入放射科,江苏徐州221002 [2]徐州医学院医学影像学院布-加综合征实验室,江苏徐州221002

出　　处：《徐州医学院学报》2013年第7期442-444,共3页Acta Academiae Medicinae Xuzhou

基　　金：江苏省科技创新与成果转化专项基金资助项目（BL2012021）;徐州医学院研究生科技创新工程研究项目（XYLC-1220）

摘　　要：目的研究布-加综合征（BCS）患者下腔静脉血中转化生长因子β1（TGF—β1）、碱性成纤维细胞生长因子（bFGF）的浓度，探讨BCS隔膜组织形成的机制。方法选取74例下腔静脉隔膜阻塞型（MOVC）BCS患者作为实验组，74例心律失常患者作为对照组。介入治疗造影前抽取2组患者的下腔静脉血，采用酶联免疫吸附法（ELISA）检测TGF—β1、bFGF的浓度。结果实验组TGF—β1浓度为（7．3±3．9）μg／L，明显高于对照组[（5．8±3．3）μg／L]，差异有统计学意义（P〈0．05）；2组间bFGF浓度的差异无统计学意义（P〉0．05）。结论BCS下腔静脉隔膜形成与血管损伤后细胞增殖、纤维化有关。Objective To investigate the serum concentration of transforming growth factor - β1 （TGF - β1 ） and basic fibroblast growth factor （bFGF） in the inferior vena cava, so as to explore the pathogenesis of the membrane formation in Budd - Chiari syndrome （BCS）. Methods There were 74 cases of membranous obstruction of inferior vena eava （MOVC） in the experimental group and 74 arrhythmic inpatients in the control group. Then the inferior vena cava blood of two groups of patients was collected in the course of interventional treatment （ before contrast medium injection）, the serum concentrations of TGF- β1 and bFGF were detected by enzyme- linked immunosorbent assay （ELlSA）. Results In the experimental group, the serum concentration of TGF - β1 [ （7.3±3.9）μg/L] was significantly higher than the control group [ （5.8±3.3 ）μg/L] （P 〈 0.05 ）. The difference in bFGF levels between the two groups was not significant （ P 〉 0. 05 ）. Conclusion The cell proliferation and fibrosis after vascular injury are related to the formation of membrane in inferior vena cava in patients with BCS.

关 键 词：转化生长因子Β1 碱性成纤维细胞生长因子 隔膜阻塞 布-加综合征 

分 类 号：R543.6[医药卫生—心血管疾病]