几个新型噁唑硼烷的制备与应用  

The Preparation and Application of two New Types of Oxazaborolidines

作　　者：荣国斌[1] 李新明[1] 张勇 

机构地区：[1]华东理工大学化学系,上海200237

出　　处：《有机化学》2000年第5期769-772,共4页Chinese Journal of Organic Chemistry

摘　　要：以(1S,2S)-2-氨基-1-(4-硝基苯)-1,3-丙二醇为原料,得到四种噁唑硼烷,原位催化硼烷不对称还原前手性芳基酮,讨论了反应温度和催化剂结构对反应结果的影响。Two new types of 1,3,2- oxaborolidines were prepared from (1S,2S) -2- arnino - 1 - (4 - nitro-phenyl) - propane - 1,3 - diol and used as catalysts in the asymmetric reduction of acetophenone. The influence of temperature as well as the effect of the structure of catalyst on the enantioselectivity is discussed. The origin of the products' configurational is explored.

关 键 词：恶唑硼烷 不对称催化还原 前手性酮 制备 应用 

分 类 号：O626[理学—有机化学]