磺胺甲噁唑的二阶导数差示脉冲极谱法测定  

Quantitative Determination of Sulfamethoxazole by Second Derivative Differential Pulse Polarography

作　　者：梁云爱 刘兆华 孙金辉[3] 

机构地区：[1]山东省日照市药品检验所,日照276800 [2]山东省五莲县人民医院 [3]中国科学院大气物理研究所,北京100029

出　　处：《分析化学》2000年第9期1136-1139,共4页Chinese Journal of Analytical Chemistry

摘　　要：建立了磺胺甲噁唑的二阶导数差示脉冲极谱定量分析方法，磺胺甲噁唑在１０％ ＨＣｌ－（硼酸－氧化钾缓冲溶液）－水（５：５：９０）的底液中，于－１．４５Ｖ（ｖｓ．Ａｇ／ＡｇＣｌ）处出现一良好的 二阶导数差示脉冲极谱峰，磺胺甲噁唑浓度与其峰高在０．０８～０．８０ｍｍｏｌ／Ｌ范围内呈线性关 系（ｐ＜ ０．０１），检测限为 ８．６ｎｍｏｌ／Ｌ。本法简便、快速、灵敏，结果准确。The second derivative differential pulse polarography was developed for the determination of the sulfamethoxazole and its preparation . In 10% HCl-buffer solution of boric acid-potassium chloride- water (5: 5: 90) solution, a good second derivative differential pulse polarographic peak appeared at -1.450 V(vs. Ag/AgCl). The linear relationship between concentration of sulfamethoxazole and peak height was obtained in the concentration range of 0.08 - 0.80 mmol/L (p<0.01). The detection limit is 8.6 nmol/L. The method is simple, rapid, sensitive. The results are accurate.

关 键 词：磺胺甲恶唑 抗菌药 二阶导数差示脉冲极谱法 

分 类 号：R978.5[医药卫生—药品] R927.2[医药卫生—药学]