纳米颗粒在抗癌药物可控靶向释放中的应用  

Application of Nanoparticles with Targeting,Triggered Release in Anti-Cancer Drug Delivery

作　　者：张磊[1] 刘晓燕[1] 沈晶晶[1] 卢晓梅[1] 范曲立[1] 黄维[1] 

机构地区：[1]南京邮电大学信息材料与纳米技术研究院有机电子与信息显示国家重点实验室培育基地,南京210023

出　　处：《化学进展》2013年第8期1375-1382,共8页Progress in Chemistry

基　　金：国家重点基础研究发展计划(973)项目(No.2012CB933301;2012CB723402);国家自然科学基金项目(No.61205195);教育部"新世纪优秀人才支持计划"项目(No.NCET-10-0179);高等学校博士点专项科研基金项目(No.20093223110003;20123223120011);江苏省高校自然科学基础研究项目(No.12KJB150018);生物电子学国家重点实验室开放研究基金(No.BJ211029)资助

摘　　要：近些年来癌症发病率不断攀升,引起了人们的普遍关注。由于传统诊疗方法存在弊端,因此开发新型的针对肿瘤组织的多功能的纳米颗粒(如金纳米颗粒、脂质体、聚合物、DNA等)药物输送系统越来越重要。基于生物体的EPR效应或经过表面修饰功能化后,纳米颗粒输送系统可被动或主动靶向到达肿瘤组织,并通过控制温度、pH、超声、光以及酶等激发条件在肿瘤区域实现可控释放。本文简单介绍了肿瘤治疗中常用的具有靶向性、可控释放的纳米颗粒载药系统,系统地描述了纳米颗粒在药物输送系统的最新研究进展,并对今后的发展方向作了展望。In recent years, the higher incidence of cancer has aroused wide public concern. Due to the drawbacks of conventional cancer treatment methods, there has been increasing interest in developing new drug targeting delivery systems with multi-functionalized nanoparticles, such as gold nanopartieles, liposomes, polymers, DNA, etc. Base on the enhanced permeability and retention （EPR） effect, the nanoparticles can present both passive and active targeting mechanisms after modified with the targeting biomoleculars on the surface. And the temperature, pH, ultrasound, light and enzymes can all act as incentives for triggered release in tumor regions. This review examines functionalities engineered into nanoparticles recently, including targeting and triggered release of contents, and these properties have raised new opportunities for drug delivery system.

关 键 词：纳米颗粒 药物输送系统 靶向 可控释放 

分 类 号：Q503[生物学—生物化学]