3.5%尿素交连明胶致血浆组织胺浓度变化及其预防  

Influence of 3.5% Gelatine Polypetides Cross linked via Urea Bridges on Plasma Histamine Concentration and Its Prevention

作　　者：陈文华[1] 林鹏焘[1] 黄其健[1] 洪燕玲[1] 陈锦娥[1] 

机构地区：[1]福建医科大学附属协和医院,福州市350001

出　　处：《临床麻醉学杂志》2000年第7期332-333,共2页Journal of Clinical Anesthesiology

摘　　要：目的 :观察 3 5 %尿素交连明胶 (UG)输入人体后血浆组织胺浓度的变化及H1和H2 受体拮抗药 (异丙嗪与法莫替丁 )的预防效应。方法 :6 0例患者随机分为三组 ,每组 2 0例 ,Ⅰ、Ⅱ组分别输注林格氏液、3 5 %UG各 5 0 0ml;Ⅲ组静注异丙嗪 12 5mg和法莫替丁 2 0mg后输液同Ⅱ组。分别于输液前、开始输液后 10、2 0及 30分钟抽取血样一次检测血浆组织胺浓度。结果 :Ⅰ组血浆组织胺浓度与输注林格氏液前比较在 2 0及 30分钟时增高 (P <0 0 5或0 0 1) ,Ⅱ、Ⅲ组的血浆组织胺浓度在输注 3 5 %UG后的 10、2 0及 30分钟升高 (P <0 0 5或 0 0 1) ,Ⅱ组与Ⅲ组比较 ,无显著性差异 (P >0 0 5 ) ,临床未发现变态反应现象。结论 :3 5 %UG可致血浆组织胺水平升高 ,但并没达到通常变态反应所需的血浆组织胺水平 (5 0ng/ml)。静注H1及H2 受体拮抗药并不能有效抑制其所致的血浆组织胺浓度的升高 。Objective:To observe the change of plasma histamine concentration caused by infusion of 3 5% gelatine polypetides cross linked via urea bridges (UG) and prevention of H 1 and H 2 receptor antagonists (promethazin and famotidine) were studied.Methods:60 patients were randomly divided into three groups.Group I received Ringer’s solution.In group Ⅱ and Ⅲ,3 5%UG was given intravenously without or with promethazin 12 5mg and famotidine 20mg.The blood was taken respectively before the infusion and at 10,20,30 min of the infusion for checking plasma histamine concentration.Results:The plasma histamine concentration in group Ⅰ increased after infusion of Ringer’s solution at 10 and 20 min ( P< 0 05 or 0 01).The concentration of plasma histamine of group Ⅱ and Ⅲ also increased at 10,20,30min after 3 5%UG ( P< 0 05 or 0 01),but there was no significant difference of it between group Ⅱ and Ⅲ.No allergic reaction was seen in all patients.Conclusion:Plasma histamine concentration may be incresed during infusion of 3 5%UG,but it is not high enough(50ng/ml)to cause allergic reaction.H 1 and H 2 receptor antagonists are not effective in preventing histamine release associated with UG infusion.It is not necessary to use H 1 and H 2 receptor as a routine.

关 键 词：尿素交连明胶 血浆组织胺 浆代用品 

分 类 号：R614[医药卫生—麻醉学]