老年正常高值血压者动态血压及节律与中心动脉反射波增强指数的关系  

Relation of ambulatory blood pressure and rhythm with central aortic reflective wave pressure AIx in elderly prehypertensive patients

作　　者：齐在文[1,2] 路方红[3] 刘振东[3] 赵颖馨[3] 

机构地区：[1]济南大学 山东省医学科学院医学与生命科学学院,250062 [2]山东省医学科学院基础医学研究所 [3]山东省医学科学院基础医学研究所心脑血管病防治研究中心

出　　处：《中华老年心脑血管病杂志》2013年第8期817-820,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：山东省科学技术发展计划(2011GSF11822)

摘　　要：目的探讨正常高值血压者动态血压及节律与中心动脉反射波增强指数的关系。方法选择正常血压者(正常组)138例,正常高值血压者(高值组)121例,高血压者(高血压组)100例,采用动态血压监测仪监测动态血压及节律;采用动脉脉搏波分析仪测量中心动脉压及增强指数(AIx)。结果与正常组比较,高值组24h平均收缩压、24h平均舒张压、昼间平均收缩压、昼间平均舒张压、夜间平均收缩压、夜间平均舒张压、中心动脉收缩压、中心动脉舒张压、中心动脉脉压、增强压、AIx均明显升高,夜间收缩压下降率明显降低(P<0.05)。正常高值血压经多元线性逐步回归分析显示,性别、年龄、吸烟、夜间收缩压下降率、非杓型血压发生率为AIx的主要影响因素。经协方差分析,血压水平与非杓型血压发生率对AIx均有影响,且有协同作用(F=12.37,P<0.05)。结论非杓型血压单独对AIx有影响,且与高水平血压有协同叠加效应。Objective To study the relation of ambulatory blood pressure and rhythm with central aortic reflective wave pressure augmentation index （AIx） in elderly prehypertensive patients. Methods Three hundred and fifty-nine subjects were divided into normotensive group （n=138）, prehypertensive group （n=121） and hypertensive group （n= 100） according to their blood pres- sure. Their ambulatory blood pressure and rhythm were monitored, and their central aortic pres- sure central pulse pressure,augmentation pressure and AIx were measured. Results The average 24 h systolic and diastolic blood pressure, daytime and nighttime systolic and diastolic blood pressure, central aortic systolic and diastolic blood pressure, and AIx were significantly higher whereas the nighttime systolic blood pressure fall was significantly lower in prehypertensive group than in normotensive group （P〈 0. 05）. Multiple linear regression analysis showed that gender, age, smoking,nighttime systolic blood pressure fall and non-dipper blood pressure were the independent risk factors for AIx. Covariance analysis revealed that blood pressure and non-dipper blood pressure were the influence factors for AIx and exerted synergistically on AIx （F=12.37,P〈 0.05）. Conclusion Non-dipper blood pressure is an independent risk factor for AIx and exerts a synergistic effect with high blood pressure on AIx.

关 键 词：高血压 昼夜节律 动脉硬化 血压测定 脉搏 

分 类 号：R544.1[医药卫生—心血管疾病]