MRI定量分析脑白质病变程度与脑体积变化关系的研究  

MRI quantitative analysis of relation between brain white matter lesion and brain volume

作　　者：欧世宁[1,2] 罗彦妮[3] 叶长青[1] 张珏[4] 黄一宁[1] 

机构地区：[1]北京大学第一医院神经内科,100034 [2]广西壮族自治区民族医院 [3]广西壮族自治区民族医院神经内二科 [4]北京大学工学院

出　　处：《中华老年心脑血管病杂志》2013年第8期831-834,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探索脑白质病变(WML)患者脑体积、WML体积变化关系及其影响因素。方法选择188例行头颅MRI检查为WML患者的图像,采用图像分割及自动体积测量软件计算颅内腔体积、脑体积及WML体积。分析不同性别、年龄(≤50岁、51～65岁、66～75岁、>75岁)的标准化脑体积(VB)和标准化WML(VWML)情况及两者之间的关系。结果 188例患者中,男性和女性VB分别为(773.79±69.90)‰和(759.69±71.59)‰,VWML分别为4.86(9.01)和4.61(11.51),差异无统计学意义(P>0.05)。与年龄>75岁比较,≤50岁、51～65岁、66～75岁患者VB均值明显增大(P<0.01)。Spearmen相关分析显示,VWML与年龄呈正相关(r=0.212,P=0.004)。校正年龄及性别因素后,偏相关分析显示,VB与WML病变程度呈负相关(r=-0.216,P=0.003)。结论 WML男性和女性VB及VWML无明显差异,随着年龄增长,WML逐渐加重,VB随着病变程度加重而明显缩小。Objective To study the relation between brain white matter lesion （WML） and brain volume and its influence factors. Methods One hundred and eighty-eight MRI-confirmed WML patients were included in this study. Their intracranial volume, brain volume and WML volume were calculated according to their magnetic resonance imge. Relation between standard brain volume and standard WML volume was analyzed in different age and gender patients. Results No significant difference was found in the brain volume and WML volume between male and female patients [773.79‰±69.90‰ vs 759.69‰±71.59‰,4.86（9.01） vs 4.61（11.51） ,P〉0.05]. The average brain volume was significantly smaller in patients aged 450 years, 51-65 years,and 66--75 years than in those aged ;75 years （P;0.01）. Spearmen correlation analysis showed that the WML volume was positively related with age （r=0. 212, P= 0. 004）. A significant difference was found in mild and severe WML after adjustment for age and gender （P〈0.01）. Partial correlation analysis revealed that the brain volume was negatively related with the WML volume （r=0. 216,P;0. 003）. Conclusion The brain volume and WML volume are not significantly different in males and females. However, the WML volume increases with age and the brain volume decreases with its severity.

关 键 词：磁共振成像 脑疾病 脑室 萎缩 认知障碍 性别因素 

分 类 号：R445.2[医药卫生—影像医学与核医学]