口服米索前列醇混悬液用于足月妊娠引产70例分析  

Study on misoprostol suspension per os for inducing term labor.

作　　者：庄桂霞[1] 苏绮枫[1] 张健[1] 谢军[1] 朱金萍[1] 程利南[1] 

机构地区：[1]中国福利会国际和平妇幼保健院,上海200030

出　　处：《中国实用妇科与产科杂志》2000年第8期481-483,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　探讨小剂量口服米索前列醇混悬液用于足月妊娠引产的有效性和安全性。方法　 140例有引产指征的足月孕妇分为两组。A组 70例口服米索混悬液 ,每 2h 1次 ,初起每次 2 0ml,连续 3次后若无规律宫缩出现 ,第 4次起改为每次 40ml,若出现有效宫缩即停药 ,否则直至服完 2 0 0ml;B组 70例静滴催产素引产作为对照组。结果　两组引产成功率分别为 88 5 7%和 82 86 % (P >0 0 5 )。A组从开始用药至临产的平均时间较B组明显缩短 (P <0 0 5 )。宫颈评分≤ 5分的产妇A组引产成功率 (84 6 1% )高于B组 (33 33% ,P <0 0 5 )。两组剖宫产率 ,产后 2h出血量及羊水污染、胎儿窘迫、新生儿窒息的发生率间差异均无显著性。结论　小剂量口服米索混悬液用于足月孕妇引产是一种安全、有效、方便的方法 ,且效果优于催产素。Objective To study the efficacy and safety of taking misoprostol suspension per os at lower dosage for inducing term labor.Methods 140 women at term with indications of labor induction were divided into two groups.70 women (group A) received misoprostol suspension(200μg/200ml):20ml at the beginning was taken every two hours,since the fourth dose,40ml was given each time until the whole 200ml was taken if the effective contractions of uterus did not appear during this peroid.Otherwise,misoprostol was stopped immediately.70 subjects of group B received intravenous oxytocin for controls.Results The success rate of labor induction was 88 57% in group A and 82 86% in group B(P>0 05).The average interval from start of labor induction to onset of labor in group A was significantly shorter than that in group B(P<0 05).When the cervix was unfavorable(Bishop score≤5),the success rate of labor induction in group A was (84 61%) higher than that in group B(33 33%)(P<0 05).There were no significant differences in the incidence of meconium-stained amniotic fluid,fetal distress,neonatal asphyxia,postpartum hemorrhage and in the number of ceserean section between the two groups.Conclusion It is safe,effective and convenient to induce term labor with misoprostol suspension in lower dosage.This method was better than that of oxytocin infusion.

关 键 词：米索前列醇 足月妊娠 药物引产 混悬液 

分 类 号：R719.31[医药卫生—妇产科学] R984[医药卫生—临床医学]