雌三醇栓治疗老年性阴道炎90例临床分析  

Clinical effect of intravaginal estriol suppository on senile vaginitis in 90 postmenopausal women.

作　　者：谢兰[1] 杨业洲[1] 陈廉[1] 程小尧[1] 迟殊[1] 饶绍琴[1] 

机构地区：[1]四川省人民医院妇产科,成都610072

出　　处：《中国实用妇科与产科杂志》2000年第8期485-487,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的　了解雌三醇栓阴道给药对老年性阴道炎的临床治疗效果。方法　对 135例老年性阴道炎妇女随机分成两组 :90例治疗组每日将含 2mg的雌三醇栓 1枚放入阴道深部 ,1周后每周放入 1枚 ,连用 8周 ;45例对照组用药为含 0 312 5mg倍美力的倍美力软膏 ,用法同治疗组。结果　治疗组和对照组用药后 ,Kupperman评分明显下降 ,阴道健康评分显著升高 ,血清雌二醇 (E2 )水平上升至卵泡早期水平 ,总胆固醇 (TC)下降 ,甘油三酯(TG)及低密度脂蛋白 (LDL)上升 ,但差异无统计学意义 ,治疗组高密度脂蛋白 (HDL)和HDL/LDL显著升高。结论　雌三醇栓能有效缓解围绝经期症候群 ,改善阴道健康状况。Objective To determine the clinical effects of intravaginal estriol suppository on senile vaginitis.Methods 135 patients were randomly divided into 2 groups:in treatment group women took one intravaginal estriol suppository (contained 2mg estriol) and in control group women took 0 5 gram intravaginal premarin cream (contains 0 3125mg premarin) per day.1 week later,drugs were taken weekly and this last 8 weeks.Kupperman and vaginal health score were observed,serum lipids, lipoprotein, estradiol, follicle stimulating hormone(FSH) and luteinizing hormone(LH) were measured before and after treatment.Results The Kupperman score decreased significantly(P<0 05) while the vaginal health score increased significantly in each group(P<0 05),serum estradiol increased to early follicle stage level and FSH and LH decreased significantly in two groups(P<0 01),high density lipoprotein(HDL) and HDL/LDL(low density lipoprotein) increased significantly in treatment group(P<0 05).Conclusion Intravaginal estriol suppository is effective in remitting the perimenopausal syndrome and improving the vaginal condition.

关 键 词：雌三醇栓老年性阴道炎 阴道给药 围征经期 

分 类 号：R588.06[医药卫生—内分泌] R711.31[医药卫生—内科学]